2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione | CAS No. 5460-29-7

Q: What are the physical and chemical properties of 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7)?

2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) is a solid with a crystalline form. The molecular weight is approximately 296.12 g/mol. It has low water solubility but good solubility in organic solvents such as dichloromethane and acetone. This compound is chemically stable but can react with strong bases to form the corresponding anion. It has limited reactivity under normal conditions but can undergo electrophilic aromatic substitution reactions.

Q: How is 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) typically synthesized?

2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) is typically synthesized via a multi-step process, involving the bromination of propyl isonitrile and subsequent reaction with isoindole. The synthesis often uses a Lewis acid catalyst such as aluminum chloride. The yield is around 70-80%, and the reaction is highly selective for the bromo substitution on the propyl group.

Q: What industries use 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7)?

2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) finds application in the pharmaceutical industry for the synthesis of certain medicinal compounds. It is also used in the polymer industry for the development of functional polymers with specific properties. Additionally, it has potential use in sensors, semiconductors, and as a reagent in organic synthesis.

Q: What precautions should be taken when handling 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7)?

When handling 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or with a fume hood. Spills should be cleaned up using appropriate absorbents and disposing of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and handling procedures.

2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione

Basic Information

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CAS Number

5460-29-7

Molecular Formula

C11H10BrNO2

Molecular Weight

268.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

72.0 to 75.0 deg-C

Boiling Point

361.4°C at 760 mmHg

Flash Point

172 ºC

Solubility

<1g/l

Refractive Index

1.6320 (estimate)

SMILES

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C1=CC=C2C(=C1)C(=O)N(C2=O)CCCBr

InChI

InChI=1S/C11H10BrNO2/c12-6-3-7-13-10(14)8-4-1-2-5-9(8)11(13)15/h1-2,4-5H,3,6-7H2

InChIKey

VKJCJJYNVIYVQR-UHFFFAOYSA-N

LogP

2.0676

Topological Polar Surface Area

37.38 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

256

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Sensitive to air

Synonyms & References

English

.gamma.-Bromopropylphthalimide
3-phthalimidopropyl bromide
UNII-VQG2G776PS
3-Bromopropylphthalimide
AM87054
2-(3-Bromopropyl)isoindoline-1,3-dione
NSC24937
SY011981
N-(bromopropyl)phthalimide
2-(3-bromopropyl)isoindoline-1,3-dione?hydrochloride
2-(3-bromo-propyl)-isoindole-1,3-dione
B1328
N-3-bromopropyl phthalimide
N-bromopropylphthalimide
N-(3-bromo-propyl)-phthalimide
InChI=1/C11H10BrNO2/c12-6-3-7-13-10(14)8-4-1-2-5-9(8)11(13)15/h1-2,4-5H,3,6-7H
1H-Isoindole-1, 2-(3-bromopropyl)-
FT-0629061
N-3-Bromopropylphthalimide
N-(3-bromopropyl) pthalimide
DTXSID40203033
1-Phthalimido-3-bromopropane
N-(3-bromopropyl) phthalimide
AKOS000277232
N-(3-BROMOPROPYL)PHTHALIMIDE
EINECS 226-738-5
Q-201421
5460-29-7
NSC-25170
2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione #
N-[3-(bromo)propyl]phthalimide

MDL Number

MFCD00005904

Customs Code

2925190090

FAQ

What are the physical and chemical properties of 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7)?

2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) is a solid with a crystalline form. The molecular weight is approximately 296.12 g/mol. It has low water solubility but good solubility in organic solvents such as dichloromethane and acetone. This compound is chemically stable but can react with strong bases to form the corresponding anion. It has limited reactivity under normal conditions but can undergo electrophilic aromatic substitution reactions.

How is 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) typically synthesized?

2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) is typically synthesized via a multi-step process, involving the bromination of propyl isonitrile and subsequent reaction with isoindole. The synthesis often uses a Lewis acid catalyst such as aluminum chloride. The yield is around 70-80%, and the reaction is highly selective for the bromo substitution on the propyl group.

What industries use 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7)?

2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7) finds application in the pharmaceutical industry for the synthesis of certain medicinal compounds. It is also used in the polymer industry for the development of functional polymers with specific properties. Additionally, it has potential use in sensors, semiconductors, and as a reagent in organic synthesis.

What precautions should be taken when handling 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7)?

When handling 2-(3-Bromopropyl)-1H-isoindole-1,3(2H)-dione (CAS: 5460-29-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or with a fume hood. Spills should be cleaned up using appropriate absorbents and disposing of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and handling procedures.