6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

Basic Information

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CAS Number

545380-34-5

Molecular Formula

C22H20N4O

Molecular Weight

356.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

169-175°C

Boiling Point

602°C at 760 mmHg

Density

1.275±0.06 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (1.0E-4 g/L) (25 ºC),

SMILES

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C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

InChI

InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)

InChIKey

IBAKVEUZKHOWNG-UHFFFAOYSA-N

LogP

4.658900000000003

Topological Polar Surface Area

73.06 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

434

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
QNZ (EVP4593)
4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
EVP4593
EVP-4593
QNZ
NF-kappaB Activation Inhibitor
N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine
N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine
InSolution™ NF-kappaB Activation Inhibitor
C22H20N4O
EVP 4593
Curator_000005
NF-kB activation inhibitor
6-amino-4-(4-phenoxyphenylethylamino) quinazoline
QNZ(EVP45
4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine
SW220245-1
DTXSID00333507
GTPL6012
HMS3229K22
545380-34-5
BCP07901
CCG-206870
HMS3748A11
s4902
DA-42127
Q0109
Q27087912
EVP4593, >=98% (HPLC)
AG-F-89549

MDL Number

MFCD06411436

Customs Code

2933990090

FAQ

What is 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline (CAS: 545380-34-5)?

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline is a complex organic compound with the CAS number 545380-34-5. It is a quinazoline derivative featuring a phenyl ring, a phenoxy group, and amino substituents. This compound is known for its potential in pharmaceutical applications, particularly as an intermediate in the synthesis of drugs.

What are the main uses of 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline (CAS: 545380-34-5)?

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline is primarily used as an intermediate in the synthesis of pharmaceuticals, particularly in the development of anti-inflammatory and analgesic drugs. It may also have applications in the development of other medicinal products.

Is 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline (CAS: 545380-34-5) safe?

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline is generally considered safe when handled with appropriate safety precautions. Users should follow standard safety guidelines, including the use of personal protective equipment, to prevent skin contact and inhalation. Storage and handling should be done in a well-ventilated area, away from heat and open flames.

How should 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline (CAS: 545380-34-5) be stored?

6-Amino-4-(4-phenoxyphenylethylamino)quinazoline should be stored in a cool, dry place, protected from light and heat. It should be kept in a tightly sealed container to prevent moisture and air exposure. The temperature should be maintained below 25°C (77°F) to ensure stability and prevent degradation.