3-aminopyrazine-2-carboxylic acid

Basic Information

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CAS Number

5424-01-1

Molecular Formula

C5H5N3O2

Molecular Weight

139.11 g/mol

EINECS

226-558-7

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

Yellow-greenish

Melting Point

205-210 °C (dec.)

Boiling Point

255.04°C (rough estimate)

Density

1.4551 (rough estimate)

Flash Point

401.3 °C at 760 mmHg

Solubility

DMSO (Sparingly) , Methanol (Slightly)

Refractive Index

1.5900 (estimate)

SMILES

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C1=CN=C(C(=N1)C(=O)O)N

InChI

InChI=1S/C5H5N3O2/c6-4-3(5(9)10)7-1-2-8-4/h1-2H,(H2,6,8)(H,9,10)

InChIKey

ZAGZIOYVEIDDJA-UHFFFAOYSA-N

LogP

-0.24300000000000038

pKa

3.65±0.10(Predicted)

Topological Polar Surface Area

89.10000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

139

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SCHEMBL65106
AI3-61137
NSC225114
HY-Y1702
Pyrazinecarboxylic acid, 3-amino-
Z56818526
FT-0614898
5424-01-1
AKOS000121386
NS00006077
3-AMINO-2-PYRAZINOIC ACID
AB00606
FT-0615066
3-aminopyrazine carboxylic acid
3-Aminopyrazine-2-carboxylicacid
EC 226-558-7
W-105651
Deacetylhypnosin
CHEMBL5205921
3-Aminopyrazine-2-carboxylic acid
DTXSID20202589
MFCD00006141
NSC135056
NSC 13148
EN300-16898
HMS1786J07
3-Amino-2-pyrazinecarboxylic acid
F8880-4479
NSC 225114
2-PYRAZINECARBOXYLIC ACID, 3-AMINO-
AC-1268

MDL Number

MFCD00006141

EC Number

226-558-7

Customs Code

29339990

FAQ

What are the physical and chemical properties of 3-aminopyrazine-2-carboxylic acid (CAS: 5424-01-1)?

3-Aminopyrazine-2-carboxylic acid is a white crystalline solid with a molecular weight of 151.16 g/mol. It is slightly soluble in water and ethanol. Chemically, it is stable under normal conditions but can react with acids and bases. It has a pKa of approximately 3.5.

How is 3-aminopyrazine-2-carboxylic acid (CAS: 5424-01-1) typically synthesized?

3-Aminopyrazine-2-carboxylic acid can be synthesized by the condensation of 2-amino-1,3-dicarbonyl compounds with hydrazine, followed by carboxylation. Commonly, hydrazine hydrate and acetic anhydride are used as reagents, yielding a pure product with a high yield. This method ensures good selectivity and is widely adopted in the literature.

What industries use 3-aminopyrazine-2-carboxylic acid (CAS: 5424-01-1)?

3-Aminopyrazine-2-carboxylic acid is used in various industries. It serves as a precursor in the synthesis of drugs, particularly in the development of antifungal agents. It also finds applications in the production of polymers, sensors, and as a component in semiconductor manufacturing processes.

What precautions should be taken when handling 3-aminopyrazine-2-carboxylic acid (CAS: 5424-01-1)?

When handling 3-aminopyrazine-2-carboxylic acid, it is essential to use personal protective equipment (PPE) such as gloves and goggles. It should be stored in a cool, dry place away from heat sources. In case of a spill, avoid contact with skin and eyes. Refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.