3-aminopyrazine-2-carboxylic acid(CAS: 5424-01-1)

3-Aminopyrazine-2-carboxylic acid is a white crystalline solid with a molecular weight of 151.16 g/mol. It is slightly soluble in water and ethanol. Chemically, it is stable under normal conditions but can react with acids and bases. It has a pKa of approximately 3.5.

3-Aminopyrazine-2-carboxylic acid can be synthesized by the condensation of 2-amino-1,3-dicarbonyl compounds with hydrazine, followed by carboxylation. Commonly, hydrazine hydrate and acetic anhydride are used as reagents, yielding a pure product with a high yield. This method ensures good selectivity and is widely adopted in the literature.

3-Aminopyrazine-2-carboxylic acid is used in various industries. It serves as a precursor in the synthesis of drugs, particularly in the development of antifungal agents. It also finds applications in the production of polymers, sensors, and as a component in semiconductor manufacturing processes.

When handling 3-aminopyrazine-2-carboxylic acid, it is essential to use personal protective equipment (PPE) such as gloves and goggles. It should be stored in a cool, dry place away from heat sources. In case of a spill, avoid contact with skin and eyes. Refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.