6-Methoxy-3,4-dihydro-2(1H)-quinolinone

Basic Information

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CAS Number

54197-64-7

Molecular Formula

C10H11NO2

Molecular Weight

177.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Yellow to Brown Solid

SMILES

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COC1=CC2=C(C=C1)NC(=O)CC2

InChI

InChI=1S/C10H11NO2/c1-13-8-3-4-9-7(6-8)2-5-10(12)11-9/h3-4,6H,2,5H2,1H3,(H,11,12)

InChIKey

XHKXYVRULOMTOW-UHFFFAOYSA-N

LogP

1.5798999999999999

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

205

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MB02321
6-methoxy-3,4-dihydrocarbostyril
6-Methoxy-2-oxo-1,2,3,4-tetrahydro-quinoline
6-Methoxy-3,4-dihydro-2(1H)-quinolinone
AC-6189
CHEMBL102738
CS-0059162
6-methoxy-3,4-dihydroquinolin-2(1H)-one
6-methoxy-3,4-dihydro-1H-quinolin-2-one
6-METHOXY-1,2,3,4-TETRAHYDROQUINOLIN-2-ONE
MFCD02179395
FS-2256
6-(methyloxy)-3,4-dihydro-2(1H)-quinolinone
A7879
SCHEMBL1764375
Z1197664819
AM807256
AKOS006344957
54197-64-7
SCHEMBL12015232
FT-0694790
DTXSID90447187
EN300-77412
XHKXYVRULOMTOW-UHFFFAOYSA-N
6-METHOXY-2-OXO-1,2,3,4-TETRAHYDROQUINOLINE
6-Methoxy-2-oxo-1,2,3,4-tetrahydroquiniline
2(1H)-QUINOLINONE, 3,4-DIHYDRO-6-METHOXY-
6-Methoxy-3,4-dihydroquinolin-2(1H)-one
6-METHOXY-2-OXO-1,2,3,4-TETRAHYDROQUINILINE
6-METHOXY-3,4-DIHYDRO-2(1H)-QUINOLINONE
6-Methoxy-3,4-dihydro-1H-quinolin-2-one

MDL Number

MFCD02179395

Customs Code

2933790090

FAQ

What are the physical and chemical properties of 6-Methoxy-3,4-dihydro-2(1H)-quinolinone (CAS: 54197-64-7)?

6-Methoxy-3,4-dihydro-2(1H)-quinolinone is a crystalline solid at room temperature with a molecular weight of approximately 204.22 g/mol. It is slightly soluble in water but has good solubility in organic solvents like ethanol and acetonitrile. The compound is moderately reactive, particularly towards nucleophiles. It can undergo ring-opening reactions and condensation with other compounds.

How is 6-Methoxy-3,4-dihydro-2(1H)-quinolinone (CAS: 54197-64-7) typically synthesized?

6-Methoxy-3,4-dihydro-2(1H)-quinolinone can be synthesized via the condensation of 2-hydroxyquinoline with methanol followed by dehydration. This reaction is typically catalyzed by acid or base catalysts such as hydrochloric acid or sodium methoxide. The yield is usually around 70-80%, and the selectivity to the desired product is good.

What industries use 6-Methoxy-3,4-dihydro-2(1H)-quinolinone (CAS: 54197-64-7)?

6-Methoxy-3,4-dihydro-2(1H)-quinolinone is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also employed in the polymer industry for the production of functional polymers and in the semiconductor industry for applications requiring specific chemical functionalities.

What precautions should be taken when handling 6-Methoxy-3,4-dihydro-2(1H)-quinolinone (CAS: 54197-64-7)?

When handling 6-Methoxy-3,4-dihydro-2(1H)-quinolinone, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.