6-Methoxy-3,4-dihydro-2(1H)-quinolinone(CAS: 54197-64-7)

6-Methoxy-3,4-dihydro-2(1H)-quinolinone is a crystalline solid at room temperature with a molecular weight of approximately 204.22 g/mol. It is slightly soluble in water but has good solubility in organic solvents like ethanol and acetonitrile. The compound is moderately reactive, particularly towards nucleophiles. It can undergo ring-opening reactions and condensation with other compounds.

6-Methoxy-3,4-dihydro-2(1H)-quinolinone can be synthesized via the condensation of 2-hydroxyquinoline with methanol followed by dehydration. This reaction is typically catalyzed by acid or base catalysts such as hydrochloric acid or sodium methoxide. The yield is usually around 70-80%, and the selectivity to the desired product is good.

6-Methoxy-3,4-dihydro-2(1H)-quinolinone is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also employed in the polymer industry for the production of functional polymers and in the semiconductor industry for applications requiring specific chemical functionalities.

When handling 6-Methoxy-3,4-dihydro-2(1H)-quinolinone, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.