Metoclopramide hydrochloride hydrate

Basic Information

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CAS Number

54143-57-6

Molecular Formula

C14H25Cl2N3O3

Molecular Weight

354.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

182.5-184°

Boiling Point

504.6°C at 760 mmHg

Water Solubility

It is very soluble in water, easily soluble in ethyl alcohol, slightly soluble in dichloromethane.

Flash Point

207°C

SMILES

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CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.O.Cl

InChI

InChI=1S/C14H22ClN3O2.ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H;1H2

InChIKey

KJBLQGHJOCAOJP-UHFFFAOYSA-N

LogP

1.5994999999999995

Topological Polar Surface Area

99.09 Å²

Hydrogen Bond Donor/Acceptor

5 / 6

Complexity

300

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Light Sensitive

Synonyms & References

English

Emperal
Metoclopramide hydrochloride [USAN:USP:JAN]
Metoclopramide hydrochloride- Bio-X
D05008
Pramiel
Gastrotablinen
METIPAMID [WHO-DD]
Mygdalon
Gastrobid
Metozolv
Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride, monohydrate
Maxeran
Metoclopramide hydrochloride monohydrate
NSC-757117
4-Amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide hydrochloride hydrate;Metoclopramide hydrochloride hydrate
KJBLQGHJOCAOJP-UHFFFAOYSA-N
metoclopramide hcl monohydrate
Gastrotem
4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide monohydrochloride monohydrate
Metoclopramide HCl H2O
METOCLOPRAMIDE HYDROCHLORIDE MONOHYDRATE [EP MONOGRAPH]
METOCLOPRAMIDE HYDROCHLORIDE [ORANGE BOOK]
DS-12081
Apo-Metoclop
METOCLOPRAMIDE HYDROCHLORIDE MONOHYDRATE [WHO-DD]
METOCLOPRAMIDE HYDROCHLORIDE [USP MONOGRAPH]
METOCLOPRAMIDE HYDROCHLORIDE [WHO-IP]
Peraprin
Metocobil
METOCLOPRAMIDE HYDROCHLORIDE [WHO-DD]
metipamid

MDL Number

MFCD00058011

FAQ

What is Metoclopramide hydrochloride hydrate (CAS: 54143-57-6)?

Metoclopramide hydrochloride hydrate is a medication used to treat gastrointestinal disorders. It is a hydrochloride salt of metoclopramide, which is a dopamine receptor antagonist. Its chemical formula is C17H22ClN3S·HCl·2H2O. It is typically a white to off-white crystalline powder with a bitter taste and is soluble in water.

What are the main uses of Metoclopramide hydrochloride hydrate (CAS: 54143-57-6)?

Metoclopramide hydrochloride hydrate is primarily used to alleviate nausea, vomiting, and gastrointestinal motility issues. It is also employed in the treatment of chemotherapy-induced nausea and as an adjunct in managing postoperative nausea. In research, it is used to study gastrointestinal function and drug interactions.

Is Metoclopramide hydrochloride hydrate (CAS: 54143-57-6) safe?

Metoclopramide hydrochloride hydrate is generally considered safe when used as directed. However, it may cause side effects such as drowsiness, restlessness, or extrapyramidal symptoms. Proper handling and storage are essential to ensure safety, and it should be kept away from children and not used in excess. Safety standards for this compound are well-established in pharmaceutical guidelines.

How should Metoclopramide hydrochloride hydrate (CAS: 54143-57-6) be stored?

Metoclopramide hydrochloride hydrate should be stored in a cool, dry place, away from direct light. It is best kept in a sealed container at a temperature below 25°C and humidity levels below 60%. Proper storage helps maintain its stability and potency over time.