6-Chloro-2-pyridinecarbaldehyde

Basic Information

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CAS Number

54087-03-5

Molecular Formula

C6H4ClNO

Molecular Weight

141.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

69.0 to 73.0 deg-C

Boiling Point

218.9°C at 760 mmHg

SMILES

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C1=CC(=NC(=C1)Cl)C=O

InChI

InChI=1S/C6H4ClNO/c7-6-3-1-2-5(4-9)8-6/h1-4H

InChIKey

XTRLIKXVRGWTKW-UHFFFAOYSA-N

LogP

1.5474999999999999

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

107

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

6-CHLORO-2-PYRIDINECARBOXALDEHYDE
J-518638
AMY1936
SCHEMBL864373
6-Chloro-2-pyridinecarbaldehyde
DTXSID40444929
C3017
AB52723
6-chloropicoline aldehyde
2-Pyridinecarboxaldehyde, 6-chloro-
CS-W005244
6-CHLORO-2-FORMYLPYRIDINE
54087-03-5
SY014102
6-chloropyridine-2-carbaldehyde, AldrichCPR
A7867
FT-0647168
XTRLIKXVRGWTKW-UHFFFAOYSA-N
6-chloropicolinaldehyde
AKOS005072830
2-CHLOROPYRIDINE-6-CARBOXALDEHYDE
FC-0603
EN300-113572
AC-6345
6-chloropyridine-2-carbaldehyde
MFCD09832941
6-Chloro-pyridine-2-carbaldehyde
6-CHLOROPYRIDINE-2-CARBOXALDEHYDE
6-Chloropyridine-2-carbaldehyde
6-Chloropicolinaldehyde
6-Chloro-2-pyridinecarboxaldehyde

MDL Number

MFCD09832941

FAQ

What are the physical and chemical properties of 6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5)?

6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5) is a crystalline solid with a molecular weight of approximately 174.64 g/mol. It has a strong characteristic odor and is poorly soluble in water but soluble in common organic solvents such as ethanol and dichloromethane. This compound is highly reactive and can undergo various electrophilic aromatic substitution reactions and condensation reactions.

How is 6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5) typically synthesized?

6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5) is commonly synthesized via the chlorination of 2-pyridinecarbaldehyde using thionyl chloride as a reagent. This process provides a high yield and good selectivity. Other methods include sequential chlorination or direct chlorination using Lewis acids as catalysts.

What industries use 6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5)?

6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various drugs and also finds applications in the production of dyes, pesticides, and as a reagent in organic synthesis.

What precautions should be taken when handling 6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5)?

When handling 6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5), proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or under a fume hood due to its strong odor and potential for inhalation hazards. Spills should be handled with appropriate absorbents and the material safety data sheet (SDS) should be consulted for detailed spill procedures.