6-Chloro-2-pyridinecarbaldehyde(CAS: 54087-03-5)

6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5) is a crystalline solid with a molecular weight of approximately 174.64 g/mol. It has a strong characteristic odor and is poorly soluble in water but soluble in common organic solvents such as ethanol and dichloromethane. This compound is highly reactive and can undergo various electrophilic aromatic substitution reactions and condensation reactions.

6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5) is commonly synthesized via the chlorination of 2-pyridinecarbaldehyde using thionyl chloride as a reagent. This process provides a high yield and good selectivity. Other methods include sequential chlorination or direct chlorination using Lewis acids as catalysts.

6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various drugs and also finds applications in the production of dyes, pesticides, and as a reagent in organic synthesis.

When handling 6-Chloro-2-pyridinecarbaldehyde (CAS: 54087-03-5), proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or under a fume hood due to its strong odor and potential for inhalation hazards. Spills should be handled with appropriate absorbents and the material safety data sheet (SDS) should be consulted for detailed spill procedures.