(1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (1:1)

Basic Information

View in Editor

CAS Number

538-09-0

Molecular Formula

C7H14ClNO

Molecular Weight

127.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

No data available

Melting Point

159-164°C

Boiling Point

229.6°C at 760 mmHg

Flash Point

116.8 ºC

Refractive Index

1.52

Vapor Pressure

No data available

SMILES

View in Editor

C1CC2CC(CC1N2)O

InChI

InChI=1S/C7H13NO.ClH/c9-7-3-5-1-2-6(4-7)8-5;/h5-9H,1-4H2;1H/t5-,6+,7?;

InChIKey

RROJVSOIIWHLCQ-VPEOJXMDSA-N

LogP

0.2616999999999999

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

104

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

CS-W019387
EN300-218694
8-Azabicyclo-3.2.1-octan-3-ol
NSC 72850
Nortropenol
SCHEMBL1023893
Nortropeno Hydrochloride
MFCD00047140
1alpha-H,5alpha-H-Nortropan-3alpha-ol
8-Azabicyclo(3.2.1)octan-3-ol, endo-
AKOS006349303
Nortropidine, 2,3-dihydro-3-hydroxy-
CCG-36431
AKOS006344688
AC-656
AKOS025310532
A829777
J-500487
538-09-0
1alphaH,5alphaH-Nortropan-3alpha-ol
501-33-7
(1S,5R)-8-AZABICYCLO[3.2.1]OCTAN-3-OL
1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol
SCHEMBL1023891
(3-endo)-8-Azabicyclo[3.2.1]octan-3-ol
HY-W018601
P10202
Nortropine
DS-16717
EN300-131843
YYMCYJLIYNNOMK-KVSKUHBBSA-N

MDL Number

MFCD00047140

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (CAS: 538-09-0)?

(1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride is a white crystalline solid with a molecular weight of around 191.8 g/mol. It has a hydrophilic character, making it soluble in water and organic solvents like ethanol and methanol. This compound is known for its reactivity, particularly in nucleophilic substitution reactions. It possesses a distinct odor and is stable under normal conditions, though it may degrade at high temperatures or in strong bases.

How is (1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (CAS: 538-09-0) typically synthesized?

(1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride is often synthesized through a multistep process starting from 8-azabicyclo[3.2.1]octan-3-one. This involves the reduction of the ketone to the alcohol, followed by the addition of hydrochloric acid to form the salt. Common procedures include using sodium borohydride for reduction and hydrochloric acid for protonation, with high selectivity and good yield typically achieved under mild conditions.

What industries use (1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (CAS: 538-09-0)?

(1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride finds applications in the pharmaceutical industry for its use as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for its ability to enhance the properties of polymers, and in the sensor industry for its reactivity in certain detection processes. Additionally, it plays a role in semiconductor manufacturing for its chemical functionality and stability.

What precautions should be taken when handling (1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (CAS: 538-09-0)?

When handling (1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride, it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat. Work should be performed in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be managed carefully, and the Material Safety Data Sheet (MSDS) should always be referenced for specific guidelines. Storage should be in a cool, dry place away from heat sources and incompatible materials.