How is (1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride (CAS: 538-09-0) typically synthesized?

(1R,5S)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride is often synthesized through a multistep process starting from 8-azabicyclo[3.2.1]octan-3-one. This involves the reduction of the ketone to the alcohol, followed by the addition of hydrochloric acid to form the salt. Common procedures include using sodium borohydride for reduction and hydrochloric acid for protonation, with high selectivity and good yield typically achieved under mild conditions.