(2E)-3-(3-Hydroxy-4-methoxyphenyl)acrylic acid

Basic Information

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CAS Number

537-73-5

Molecular Formula

C10H10O4

Molecular Weight

194.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

230 °C (dec.)

Boiling Point

410.2℃ at 760 mmHg

Flash Point

167.6±19.4 °C

Solubility

Soluble in ethanol and methanol.

Refractive Index

1.5168 (estimate)

SMILES

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COc1ccc(cc1O)/C=C/C(=O)O

InChI

InChI=1S/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+

InChIKey

QURCVMIEKCOAJU-HWKANZROSA-N

LogP

1.4986

Topological Polar Surface Area

66.76 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

224

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Synonyms & References

English

3-(3-Hydroxy-4-methoxyphenyl)acrylic acid
(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
Isoferulic acid
3-Hydroxy-4-methoxycinnamic acid
3-Hydroxy-4-methoxycinnamic Acid (Isoferulic Acid)
ISOFERULIC ACID(P) PrintBack
ISOFERULIC ACID(RG)
3'-hydroxy-4'-methoxy cinnamic acid
3-Hydroxy-4-methoxycinnamic
Caffeic acid 4-methyl ether
Hesperetic Acid
HESPERETINIC ACID
Hesperitinic acid
Isoferulic
RARECHEM BK HW 0093
trans-3-hydroxy-4-methoxycinnamic acid
trans-isoferulic acid
WAKO085-08691
Cinnamicacid, 3-hydroxy-4-methoxy- (7CI,8CI)
4-Methoxycaffeic acid
4-O-Methylcaffeic acid
NSC 51987
Isoferulicacid
Isoferulate
Hesperetate
(E)-3-(3-hydroxy-4-methoxyphenyl)acrylic acid
2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-
3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
3-hydroxy-4-methoxy-cinnamic acid
QURCVMIEKCOAJU-HWKANZROSA-N
Cinnamic acid, 3-

MDL Number

MFCD00004391

Customs Code

29189090

FAQ

What is (2E)-3-(3-Hydroxy-4-methyoxyphenyl)acrylic acid (CAS: 537-73-5)?

It is a chemical compound with the formula C14H14O4, characterized by a conjugated double bond and a hydroxy-methoxy substituted phenyl group. This compound is a colorless liquid with a mild aromatic odor, commonly used as an intermediate in pharmaceutical and organic synthesis. Its molecular structure includes a carboxylic acid functional group linked to a para-hydroxy, meta-methoxy phenyl ring, making it valuable in drug development and research.

What are the main uses of (2E)-3-(3-Hydroxy-4-methyoxyphenyl)acrylic acid (CAS: 537-73-5)?

The compound is primarily used in pharmaceuticals as a building block for drug molecules, in industrial applications for polymer synthesis, and in food science as a flavoring agent. It also serves as a research tool for studying aromatic substitution reactions and biological activity. Its versatility stems from the reactivity of the acrylic acid group and the functional groups on the phenyl ring.

Is (2E)-3-(3-Hydroxy-4-methyoxyphenyl)acrylic acid (CAS: 537-73-5) safe?

When handled properly, it is considered safe. However, as a chemical intermediate, it requires adherence to safety protocols. Precautions include wearing gloves, goggles, and a lab coat, and ensuring adequate ventilation. Safety data sheets (SDS) recommend avoiding skin and eye contact, while its toxicity is generally low under standard conditions. Always follow OSHA and EPA guidelines for safe use.

How should (2E)-3-(3-Hydroxy-4-methyoxyphenyl)acrylic acid (CAS: 537-73-5) be stored?

Store in a cool, dry place (25°C), away from light and moisture. Use airtight, sealed containers to maintain stability and prevent degradation. Keep in a well-ventilated area to avoid exposure to fumes. It is stable under normal storage conditions but should be protected from heat and humidity to ensure longevity and safety.