(S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol

Basic Information

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CAS Number

53230-10-7

Molecular Formula

C17H16F6N2O

Molecular Weight

378.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

242-244°C

SMILES

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C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O

InChI

InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2/t12-,15+/m1/s1

InChIKey

XEEQGYMUWCZPDN-DOMZBBRYSA-N

LogP

4.447900000000002

Topological Polar Surface Area

45.150000000000006 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

483

Synonyms & References

English

4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,S*)-(+/-)-
CHEMBL172
(S,R)-MEFLOQUINE
Lariam
HY-17437
(-)-(11S,2'R)-erythro-Mefloquine
MEFLOQUINE [MI]
NCGC00161831-02
Q27084116
NSC-790109
(+)-(11S,2'R)-erythro-Mefloquine
cid_65329
BDBM50151865
SMR000875233
(DL-erythro-.alpha.-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol
RO 13-7225
NSC-758233
4-Quinolinemethanol, .alpha.-[(2R)-2-piperidinyl]-2,8-bis(trifluoromethyl)-, (.alpha.S)-, rel-
MEFLOQUINE [HSDB]
DTXCID001473959
Mephloquine
(S)-[2,8-bis(trifluoromethyl)-4-quinolinyl]-[(2R)-2-piperidinyl]methanol;hydrochloride
D04895
4-Quinolinemethanol, alpha-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, (alphaS)-rel-
MMV000016
MEFLOQUINE [USAN]
((R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl)-(2-piperidyl)methanol
(S)-[2,8-bis(trifluoromethyl)-4-quinolyl]-[(2R)-2-piperidyl]methanol;hydrochloride
CHEBI:63609
mefloquine
MMV000014

MDL Number

MFCD00869324

FAQ

What are the physical and chemical properties of (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7)?

This compound is a crystalline solid with a high molecular weight and low solubility in water. It has a high reactivity towards nucleophiles and electrophiles. The physical properties include a melting point of 270-272°C, and the chemical properties include its ability to undergo nucleophilic substitution and electrophilic aromatic substitution reactions.

How is (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7) typically synthesized?

This compound is synthesized via a multistep synthesis involving the reaction of 2,8-bis(trifluoromethyl)quinoline with (2R)-2-piperidinylmethanol. Commonly, the reaction is catalyzed by an acid or base, with high yield and good selectivity. The process requires careful control of temperature and reaction time.

What industries use (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7)?

This compound is primarily used in the pharmaceutical industry for its biological activity. It also has applications in the polymer industry for enhancing the performance of certain polymers and in the sensor industry for detecting specific chemical species.

What precautions should be taken when handling (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7)?

Handling this compound requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be performed in a fume hood to minimize exposure. Spills should be handled carefully using appropriate containment and cleaning procedures. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.

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Compound Q&A

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Compound Q&A

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(S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol | CAS No. 53230-10-7

Basic Information

CAS Number

Molecular Formula

Molecular Weight

Chemical Classification

Basic Physical Properties

Melting Point

Chemical Properties

SMILES

InChI

InChIKey

LogP

Topological Polar Surface Area

Hydrogen Bond Donor/Acceptor

Complexity

Synonyms & References

English

MDL Number

FAQ

What are the physical and chemical properties of (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7)?

How is (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7) typically synthesized?

What industries use (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7)?

What precautions should be taken when handling (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol (CAS: 53230-10-7)?

Related Compounds

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