1-Chloro-3-fluoro-2-methoxybenzene

Basic Information

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CAS Number

53145-38-3

Molecular Formula

C7H6ClFO

Molecular Weight

160.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

186.4℃ at 760 mmHg

SMILES

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COC1=C(C=CC=C1Cl)F

InChI

InChI=1S/C7H6ClFO/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,1H3

InChIKey

QASFEHCRPLPGES-UHFFFAOYSA-N

LogP

2.4877000000000002

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

110

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

53145-38-3
DTXSID20378571
EN300-7304882
SCHEMBL1703057
2-Chloro-6-fluoro anisole
1-Chloro-3-fluoro-2-methoxybenzene, AldrichCPR
2-Chloro-6-fluoroanisole
MFCD01631573
2-Chloro-6-fluorophenol, methyl ether
FT-0676212
A7737
1-chloro-3-fluoro-2-methoxybenzene
1-chloro-3-fluoro-2-methoxy-benzene
PS-8769
CS-W013269
AKOS006227787
AM20050268
1-chloro-3-fluoro-2-methoxyBenzene

MDL Number

MFCD01631573

Customs Code

2909309090

FAQ

What are the physical and chemical properties of 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3)?

1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) is a crystalline solid with a molecular weight of approximately 171.6 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is moderately reactive, especially towards nucleophiles and electrophiles, and it can undergo electrophilic aromatic substitution reactions. It has a melting point of around 56-58°C and a boiling point of about 180-182°C at atmospheric pressure.

How is 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) typically synthesized?

1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) can be synthesized through a series of reactions, including the chlorination of 3-fluoro-2-methoxybenzene with chlorine gas in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction is typically carried out in an inert solvent like dichloromethane at room temperature. The yield is usually around 70-80%, and the reaction is selective towards the chlorination of the meta-position.

What industries use 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3)?

1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for the production of special polymers. Additionally, this compound has applications in the sensor industry due to its specific chemical properties and reactivity. Its use in semiconductor manufacturing is limited but can be found in certain specialized processes.

What precautions should be taken when handling 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3)?

When handling 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation exposure. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always follow the safety data sheet (SDS) for detailed handling and emergency procedures. Storage should be in a cool, dry place away from incompatible materials and heat sources.