Compound Q&A

How is 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) typically synthesized?

Answer

1-Chloro-3-fluoro-2-methoxybenzene
1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) can be synthesized through a series of reactions, including the chlorination of 3-fluoro-2-methoxybenzene with chlorine gas in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction is typically carried out in an inert solvent like dichloromethane at room temperature. The yield is usually around 70-80%, and the reaction is selective towards the chlorination of the meta-position.

About

CAS No 53145-38-3
English Name 1-Chloro-3-fluoro-2-methoxybenzene
Molecular Formula C7H6ClFO
Molecular Weight 160.58 g/mol
SMILES COC1=C(C=CC=C1Cl)F
InChIKey QASFEHCRPLPGES-UHFFFAOYSA-N
Last Updated: 2025-09-29 09:43

Related Q&A

Compound Q&A

What are the physical and chemical properties of 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3)?

1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) is a crystalline solid with a molecular weight ...

Compound Q&A

What industries use 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3)?

1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3) is primarily used in the pharmaceutical industr...

Compound Q&A

What precautions should be taken when handling 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3)?

When handling 1-Chloro-3-fluoro-2-methoxybenzene (CAS: 53145-38-3), it is essential to wear appropri...

Compound Q&A

What is 6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one (CAS: 21889-89-4)?

6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one is a cyclic ketone with a molecular for...

21889-89-46-Methyl-7-oxabicycl...
Compound Q&A

What is 4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid (CAS: 906353-00-2)?

4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid is a chemical compound with the CAS nu...

906353-00-24-[(6-Methyl-2-pyraz...
Compound Q&A

What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?

2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8) is a colorless to slightly yel...

49745-42-82-(2-Pyridinyl)-1,3-...
Compound Q&A

What is 2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile (CAS: 24783-42-4)?

2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile is an organic compound with the CA...

24783-42-42-(6-Chloro-2-pyridi...