N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide

Basic Information

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CAS Number

5294-61-1

Molecular Formula

C14H21N3O

Molecular Weight

247.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Powder

Melting Point

116.0 to 120.0 deg-C

Boiling Point

411.2°C at 760 mmHg

Density

1.1±0.1 g/cm3

Flash Point

202.5±28.7 °C

SMILES

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CC1=C(C(=CC=C1)C)NC(=O)CN2CCNCC2

InChI

InChI=1S/C14H21N3O/c1-11-4-3-5-12(2)14(11)16-13(18)10-17-8-6-15-7-9-17/h3-5,15H,6-10H2,1-2H3,(H,16,18)

InChIKey

NJKRFQIWDJSYOK-UHFFFAOYSA-N

LogP

1.1471399999999998

Topological Polar Surface Area

44.370000000000005 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

266

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

CHEMBL1346682
EC 610-916-8
CVT 2738
AKOS000266675
Ranolazine metabolite CVT-2738
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine
n-(2,6-dimethylphenyl)-1-piperazin-acetamide
n-(2, 6-dimethylphenyl)-1-piperazineacetamide
1-[N-(2,6-Dimethylphenyl)carbamoylmethyl]piperazine
1-[(2,6-dimethylphenyl)aminocarbonylmethyl] piperazine
SCHEMBL1777934
N-(2,6-dimethylphenyl)-piperazin-1-yl-acetamide
n-(2,6-dimethylphenyl)-1-piperazineacetamide
MLS000567347
Q-102800
1-[N-(2, 6-dimethylphenyl) carbamoylmethyl]piperazine
DTXSID60967408
D4319
BDBM625996
N-(2,6-dimethylphenyl)-2-piperazin-1-yl-acetamide
FS-2651
AC-5903
N-(2,6-dimethylphenyl)-1-piperazine-acetamide
N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide; N-(2,6-Dimethylphenyl)-1-piperazineacetamide; Ranolazine Related Compound C (USP); Ranolazine Related Compound C
UNII-NYS3I6283HCVT 2738
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine;1-[N-(2,6-dimethylphenyl)carbamoylmethyl]piperazine;RZ-2;1-(2,6-Dimethylphenyl)-1-Piperazineacetamide
2-(1-Piperazinyl)-N-(2,6-dimethylphenyl)acetamide (dmpipa)
1-Piperazineacetamide, N-(2,6-dimethylphenyl)-
5294-61-1
MFCD06384973
FT-0635604

MDL Number

MFCD06384973

Customs Code

2933599090

FAQ

What are the physical and chemical properties of N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide (CAS: 5294-61-1)?

N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide is a white to off-white crystalline solid. It has a molecular weight of approximately 299.42 g/mol. This compound is sparingly soluble in water but more soluble in organic solvents like ethanol and acetonitrile. It shows moderate reactivity towards basic conditions and is stable under neutral conditions. It's not particularly flammable and has a melting point around 130-135°C.

How is N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide (CAS: 5294-61-1) typically synthesized?

N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide is typically synthesized via the condensation of 2-(1-piperazinyl)acetic acid with 2,6-dimethylbenzylamine. The reaction is catalyzed by a mild base such as potassium carbonate. The yield is around 85-90%, and the product can be isolated by recrystallization from ethanol. The process involves good selectivity and is relatively straightforward.

What industries use N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide (CAS: 5294-61-1)?

N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide is used in the pharmaceutical industry as an intermediate for the synthesis of certain drugs. It also finds applications in the polymer industry for enhancing certain properties of polymer materials. Additionally, due to its chemical structure, it can be used in sensor technologies and semiconductor manufacturing processes.

What precautions should be taken when handling N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide (CAS: 5294-61-1)?

When handling N-(2,6-Dimethylphenyl)-2-(1-piperazinyl)acetamide, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Ensure that all handling is done in a well-ventilated area or under a fume hood to avoid inhalation of dust. Spills should be cleaned up using appropriate absorbents and the area should be rinsed with water. Always consult the Material Safety Data Sheet (MSDS) for detailed safety guidelines and emergency procedures.