2-Methoxybenzoic acid

Basic Information

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CAS Number

529-75-9

Molecular Formula

C8H8O3

Molecular Weight

152.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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COC1=CC=CC=C1C(=O)O

InChI

InChI=1S/C8H8O3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3,(H,9,10)

InChIKey

ILUJQPXNXACGAN-UHFFFAOYSA-N

LogP

1.3934

pKa

4.08(at 25℃)

Topological Polar Surface Area

46.53 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

144

Synonyms & References

English

529-75-9
InChI=1/C8H8O3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3,(H,9,10
ortho-methoxybenzoic acid
AMY293
49WA6Z7GZA
MFCD00002431
CHEMBL192311
2-Anisic acid
METHOXYBENZOIC ACID, O-
FEMA 3943
A1729
methyl salicylic acid
NSC3778
Salicylic acid methyl ether
o-Methoxybenzoic acid
o-Anisic acid, >=99%
Q2018545
O-Anisic acid, 8CI
HMS1545N15
F9995-1670
anisole carboxylic acid
Kyselina 2-methoxybenzoova [Czech]
O-Methylsalicylic acid
FT-0612820
NS00015109
71F
Kyselina 2-methoxybenzoova
BENZOIC ACID,2-METHOXY
W-105423
DTXSID3060376
O-Methoxy benzoic acid

MDL Number

MFCD00002431

Customs Code

2916399090

FAQ

What are the physical and chemical properties of 2-Methoxybenzoic acid (CAS: 529-75-9)?

2-Methoxybenzoic acid (CAS: 529-75-9) is a crystalline solid with a molecular weight of approximately 158.15 g/mol. It has a pKa of around 3.7, making it a weak acid. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It exhibits typical carboxylic acid reactivity, including esterification and neutralization reactions.

How is 2-Methoxybenzoic acid (CAS: 529-75-9) typically synthesized?

2-Methoxybenzoic acid is commonly synthesized via the methylation of benzoic acid using methyl iodide and a catalytic amount of sodium hydroxide. The reaction proceeds under basic conditions, with the methyl group being introduced at the oxygen atom in the methoxy group. The yield is typically around 80-85%, and the reaction is carried out in polar aprotic solvents like dimethylformamide (DMF) or dimethyl sulfoxide (DMSO).

What industries use 2-Methoxybenzoic acid (CAS: 529-75-9)?

2-Methoxybenzoic acid (CAS: 529-75-9) is used in various industries. In pharmaceuticals, it serves as an intermediate in the synthesis of several drugs. In the polymer industry, it is used as a plasticizer and stabilizer. It is also employed in the production of sensors and semiconductors due to its chemical reactivity and stability.

What precautions should be taken when handling 2-Methoxybenzoic acid (CAS: 529-75-9)?

When handling 2-Methoxybenzoic acid (CAS: 529-75-9), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up promptly using appropriate absorbents, and the area should be thoroughly washed down with water. Refer to the Material Safety Data Sheet (MSDS) for detailed safety and handling instructions.