1-Methyl-3-phenylpiperazine

Basic Information

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CAS Number

5271-27-2

Molecular Formula

C11H16N2

Molecular Weight

176.26 g/mol

Basic Physical Properties

Melting Point

56-60 °C

Boiling Point

85 ºC (0.5 mmHg)

Density

0.991

Flash Point

85°C/0.5mm

SMILES

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CN1CCNC(C1)C2=CC=CC=C2

InChI

InChI=1S/C11H16N2/c1-13-8-7-12-11(9-13)10-5-3-2-4-6-10/h2-6,11-12H,7-9H2,1H3

InChIKey

IRMBVBDXXYXPEW-UHFFFAOYSA-N

LogP

1.2626999999999995

Topological Polar Surface Area

15.27 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

152

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 (6.1) Class 8 (6.1)

Sensitiveness

Air Sensitive

Synonyms & References

English

AKOS016323497
PIPERAZINE, 1-METHYL-3-PHENYL-
3-Phenyl-1-methylpiperazine, (+/-)-
1-methyl-3-phenyl-piperazine
CHEMBL2177127
AB14171
CS-W003047
1-Methyl-3-phenylpiperazine, 97%
5271-27-2
HMS1788L18
AKOS000266736
NS00015354
(+/-)-3-PHENYL-1-METHYLPIPERAZINE
1-methyl-3-phenyl piperazine
SCHEMBL90572
BCP22012
SB46668
AM85340
FS-1661
FT-0658887
Q27255866
M1685
AC-14445
EC 431-180-2
Z104508454
dl-1-methyl-3-phenyl-piperazine
EN300-13495
A7704
A844449
UNII-2ZO535841F
FT-0635596

MDL Number

MFCD03411603

Customs Code

2933599090

FAQ

What regulatory guidelines apply to 1-Methyl-3-phenylpiperazine (CAS: 5271-27-2)?

1-Methyl-3-phenylpiperazine (CAS: 5271-27-2) is subject to various regulatory guidelines. Globally Harmonized System (GHS) classifications categorize it as a substance of low acute toxicity. Under REACH regulations, manufacturers and importers are required to conduct hazard assessments and register the substance if the tonnage threshold is exceeded. Additionally, the U.S. Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) regulate its use and disposal in pharmaceuticals and industrial processes. Compliance with these regulations ensures safe handling and disposal.

Are there alternatives to 1-Methyl-3-phenylpiperazine (CAS: 5271-27-2) in synthesis?

There are several alternatives to 1-Methyl-3-phenylpiperazine (CAS: 5271-27-2) in synthesis, such as other piperazine derivatives like 1-Ethyl-3-phenylpiperazine or 1-Butyl-3-phenylpiperazine. These alternatives can provide similar functional groups and properties but with different substituents. Other common reagents include substituted pyrrolidines and morpholines, which can be used as substitutes depending on the specific reaction conditions and desired product structure.

What is the market or research trend for 1-Methyl-3-phenylpiperazine (CAS: 5271-27-2)?

The market for 1-Methyl-3-phenylpiperazine (CAS: 5271-27-2) is driven by its applications in pharmaceuticals and research, particularly as a precursor for other piperazine derivatives. Recent research trends focus on its role in drug discovery and development, as well as its potential in treating various neurological conditions. Market demand is expected to grow due to increasing pharmaceutical R&D activities. However, price trends can fluctuate based on supply and demand dynamics in these industries.

How should waste containing 1-Methyl-3-phenylpiperazine (CAS: 5271-27-2) be handled?

Waste containing 1-Methyl-3-phenylpiperazine (CAS: 5271-27-2) should be collected in appropriate containers and stored in a secure area. For incineration, ensure it meets local and national waste incineration standards. For professional disposal, consult local waste management facilities or chemical waste disposal services. Implement strict environmental protection precautions, such as proper ventilation and personal protective equipment, to prevent exposure and environmental contamination. Ensure all waste disposal aligns with regulatory requirements for hazardous waste management.