4-(4-Methoxyphenyl)-1-butanol

Basic Information

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CAS Number

52244-70-9

Molecular Formula

C11H16O2

Molecular Weight

180.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Melting Point

3-4 °C

Boiling Point

160-161 °C/8 mmHg

Density

1.042 g/mL at 25 °C

Refractive Index

n20/D 1.526(lit.)

SMILES

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COC1=CC=C(C=C1)CCCCO

InChI

InChI=1S/C11H16O2/c1-13-11-7-5-10(6-8-11)4-2-3-9-12/h5-8,12H,2-4,9H2,1H3

InChIKey

ONIBHZIXCLTLNO-UHFFFAOYSA-N

LogP

2.0101999999999998

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

117

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Benzenebutanol,4-methoxy-
UNII-WMU2T7GN3K
SCHEMBL1171813
W-105842
NSC141198
4-(4-Methoxyphenyl)-1-butanol
Benzenebutanol, 4-methoxy-
NS00032465
AKOS009157848
GS-3438
4-(p-Methoxyphenyl)-1-butanol
DTXSID60200286
4-[4-(methyloxy)phenyl]-1-butanol
NSC 141198
4-(4-methoxyphenyl)butanol
FT-0616644
p-(4-hydroxybutyl)-anisole
4-(p-Methoxyphenyl)butanol
AN-584/43485240
52244-70-9
1-Butanol, 4-(p-methoxyphenyl)-
4-(4-hydroxybutyl)anisole
MFCD00002972
4-Methoxybenzenebutanol
O11072
p-(4-hydroxybutyl)anisole
4-(1-Hydroxybut-4-yl)anisole
SY025588
4-(4-Methoxyphenyl)butan-1-ol
4-(4-Methoxyphenyl)-1-butanol, 99%
EN300-316915

MDL Number

MFCD00002972

Customs Code

2909499000

FAQ

What are the physical and chemical properties of 4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9)?

4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9) is a colorless liquid with a molecular weight of 190.23 g/mol. It has a high boiling point of 227°C and a low water solubility. This compound is less reactive but can undergo electrophilic substitution reactions. It is widely used in pharmaceuticals and cosmetics due to its chemical stability and functional groups.

How is 4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9) typically synthesized?

4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9) is commonly synthesized via a Friedel-Crafts alkylation reaction using 4-methoxyphenyl magnesium bromide and 1-bromobutane. This method provides a high yield of the desired product with good regioselectivity. The reaction is typically performed under anhydrous conditions to avoid side reactions.

What industries use 4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9)?

4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9) is utilized in multiple industries, including pharmaceuticals, cosmetics, and agrochemicals. In pharmaceuticals, it serves as a precursor to various drug molecules. In cosmetics, it is used as a skin care ingredient due to its moisturizing properties. Its use in agrochemicals is also noted for its role in developing plant growth regulators.

What precautions should be taken when handling 4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9)?

When handling 4-(4-Methoxyphenyl)-1-butanol (CAS: 52244-70-9), it is essential to wear proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the use of a fume hood to minimize inhalation risks. In case of a spill, immediately clean up using appropriate absorbents and follow local safety protocols. Always refer to the safety data sheet (SDS) for comprehensive handling guidelines.