1H-Indol-4-amine

Basic Information

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CAS Number

5192-23-4

Molecular Formula

C8H8N2

Molecular Weight

132.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

106-109 °C

Boiling Point

354 oC at 760 mmHg

Density

1.2680

Flash Point

354 oC at 760 mmHg

Refractive Index

1.757

SMILES

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C1=CC(=C2C=CNC2=C1)N

InChI

InChI=1S/C8H8N2/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5,10H,9H2

InChIKey

LUNUNJFSHKSXGQ-UHFFFAOYSA-N

LogP

1.7501

Topological Polar Surface Area

41.81 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

124

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class AIR SENSITIVE Class AIR SENSITIVE

Class IRRITANT-HARMFUL Class IRRITANT-HARMFUL

Class KEEP COLD Class KEEP COLD

Sensitiveness

Air Sensitive

Synonyms & References

English

indol-4-ylamine
GEO-00149
A828850
1H-Indol-4-amine
CHEBI:183733
MFCD01076559
5192-23-4
A3574
AM20080764
BIDD:GT0125
4-amino-1H-indol
W-202957
4-Aminoindole, 97%
Z970344664
SB14952
2P-050
4-amino-1h-indole
DTXSID50342629
1H-Indol-4-ylamine
4-aminoindol
SY004698
FT-0617577
A-5600
4-amino indole
AKOS005206886
EN300-61787
4-Aminoindole
1H-indol-4-amine;4-AMINOINDOLE
Q63409535
CS-W002745
1H-indol-4-yl-amine

MDL Number

MFCD01076559

Customs Code

29339990

FAQ

What are the physical and chemical properties of 1H-Indol-4-amine (CAS: 5192-23-4)?

1H-Indol-4-amine (CAS: 5192-23-4) is a crystalline solid with a molecular weight of approximately 129.15 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. Chemically, it is known for its basic nature and ability to form salts with acids. It is stable under normal conditions but reacts with strong acids to form indole derivatives.

How is 1H-Indol-4-amine (CAS: 5192-23-4) typically synthesized?

1H-Indol-4-amine can be synthesized through various methods, including the reduction of indole-4-carboxylic acid or indole-4-acetic acid using reducing agents like sodium borohydride or lithium aluminum hydride. Another common method involves the deamination of indole-4-acetic acid using catalytic hydrogenation or other chemical means.

What industries use 1H-Indol-4-amine (CAS: 5192-23-4)?

1H-Indol-4-amine (CAS: 5192-23-4) is primarily used in the pharmaceutical industry for the synthesis of indole derivatives that have medicinal applications. It also finds use in the polymer industry as a precursor for certain polymeric materials and in the sensor and semiconductor industries for the development of gas sensors and electronic components.

What precautions should be taken when handling 1H-Indol-4-amine (CAS: 5192-23-4)?

When handling 1H-Indol-4-amine (CAS: 5192-23-4), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and lab coats. It should be stored in a cool, dry place, away from direct sunlight and heat sources. In the case of a spill, it should be contained and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling guidelines and emergency procedures.