N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide | CAS No. 51803-78-2

Q: What is N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2)?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) is an organic compound with the molecular formula C15H13N2O5S. It features a sulfonamide group attached to a 4-nitro-2-phenoxyphenyl ring, making it a key intermediate in pharmaceutical and chemical synthesis. The compound is typically a solid at room temperature and exhibits moderate solubility in polar solvents. Its structure is relevant in drug development and research applications involving sulfonamide derivatives.

Q: What are the main uses of N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2)?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) is primarily used in pharmaceutical research as a precursor for drug development, particularly in the synthesis of anti-inflammatory and antimicrobial agents. It also finds applications in organic chemistry for creating complex molecules and in industrial processes requiring sulfonamide-functional compounds. Its utility stems from its reactivity and structural versatility in chemical reactions and compound design.

Q: Is N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2) safe?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) requires careful handling due to potential toxicity. It may cause skin and eye irritation, and inhalation should be avoided. Safety guidelines recommend using personal protective equipment (PPE) such as gloves, goggles, and lab coats. Proper disposal and adherence to OSHA standards are essential to minimize health and environmental risks.

Q: How should N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2) be stored?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) should be stored in a cool, dry place (15-25°C), away from light and moisture. Keep in a sealed, airtight container to maintain stability. Avoid exposure to incompatible substances and ensure storage in a well-ventilated area. Proper labeling and adherence to chemical storage protocols are critical for safety and longevity.

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

Basic Information

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CAS Number

51803-78-2

Molecular Formula

C13H12N2O5S

Molecular Weight

308.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

148.0 to 152.0 deg-C

Boiling Point

442 oC at 760 mmHg

Density

1.451

Water Solubility

Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.

Flash Point

221.1oC

SMILES

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CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2

InChI

InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

InChIKey

HYWYRSMBCFDLJT-UHFFFAOYSA-N

LogP

4.43560

Complexity

450

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Stability

Stable. Incompatible with strong oxidizing agents.

Toxicity

LD50 orally in rats: 324 mg/kg (Swingle, Moore)

Synonyms & References

English

NCGC00015725-03
HMS1922K17
EU-0100855
NIM-03
Q20994
BRD-K76775527-001-06-2
EINECS 257-431-4
N-(4-nitro-2-phenoxyphenyl)
CCG-39319
NCGC00015725-04
A828786
SCHEMBL24882
NIMESULIDE (MART.)
R805
HMS3655D13
SR-01000000218-2
BDBM50056999
HMS1362G05
4-Nitro-2-phenoxy-methanesulfonanilide
AC-4524
SDCCGSBI-0050831.P004
HMS3712H09
DTXCID1017250
BSPBio_001103
HMS3262L11
SBI-0050831.P003
nimesulide
NCGC00015725-02
Tox21_110207
NIMESULIDE [EP MONOGRAPH]
1364966-82-4

MDL Number

MFCD00079470

FAQ

What is N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2)?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) is an organic compound with the molecular formula C15H13N2O5S. It features a sulfonamide group attached to a 4-nitro-2-phenoxyphenyl ring, making it a key intermediate in pharmaceutical and chemical synthesis. The compound is typically a solid at room temperature and exhibits moderate solubility in polar solvents. Its structure is relevant in drug development and research applications involving sulfonamide derivatives.

What are the main uses of N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2)?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) is primarily used in pharmaceutical research as a precursor for drug development, particularly in the synthesis of anti-inflammatory and antimicrobial agents. It also finds applications in organic chemistry for creating complex molecules and in industrial processes requiring sulfonamide-functional compounds. Its utility stems from its reactivity and structural versatility in chemical reactions and compound design.

Is N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2) safe?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) requires careful handling due to potential toxicity. It may cause skin and eye irritation, and inhalation should be avoided. Safety guidelines recommend using personal protective equipment (PPE) such as gloves, goggles, and lab coats. Proper disposal and adherence to OSHA standards are essential to minimize health and environmental risks.

How should N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS: 51803-78-2) be stored?

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide (CAS 51803-78-2) should be stored in a cool, dry place (15-25°C), away from light and moisture. Keep in a sealed, airtight container to maintain stability. Avoid exposure to incompatible substances and ensure storage in a well-ventilated area. Proper labeling and adherence to chemical storage protocols are critical for safety and longevity.