Telmisartan sodium

Basic Information

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CAS Number

515815-47-1

Molecular Formula

C33H29N4NaO2

Molecular Weight

536.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)[O-])C=C(C=C2C)C5=NC6=CC=CC=C6N5C.[Na+]

InChI

InChI=1S/C33H30N4O2.Na/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39;/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39);/q;+1/p-1

InChIKey

RSGAIWOEJXRYRV-UHFFFAOYSA-M

LogP

5.92970

Complexity

837

Synonyms & References

English

TELMISARTAN SODIUM
sodium,2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoate
UNII-K15TQY55Q7
4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid sodium salt
Telmisartan sodium salt
(1,1'-Biphenyl)-2-carboxylic acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-, sodium salt (1:1)
515815-47-1
sodium;2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoate
4'-[[4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid sodium salt
Q27281812
F16429
Telmisartan sodium
SCHEMBL3273737
DTXSID50199539
K15TQY55Q7
RSGAIWOEJXRYRV-UHFFFAOYSA-M

MDL Number

MFCD09027988

FAQ

What are the physical and chemical properties of Telmisartan sodium (CAS: 515815-47-1)?

Telmisartan sodium is a white or off-white crystalline powder with a molecular weight of approximately 457.71 g/mol. It is slightly soluble in water and highly soluble in sodium hydroxide solution. Telmisartan sodium is relatively stable under normal conditions but may react with acids, particularly sulfuric acid. It is widely used in pharmaceutical applications due to its hydrolytic stability.

How is Telmisartan sodium (CAS: 515815-47-1) typically synthesized?

Telmisartan sodium is synthesized through multistep organic reactions. The key steps include the coupling of an aromatic amine with a carboxylic acid followed by a condensation reaction. The process typically uses palladium catalysts and involves protecting groups to enhance selectivity and yield. The final product is obtained with a yield of approximately 70-80%.

What industries use Telmisartan sodium (CAS: 515815-47-1)?

Telmisartan sodium is primarily used in the pharmaceutical industry. It serves as a prodrug for telmisartan, which is an angiotensin II receptor antagonist used to treat hypertension and heart failure. It is also used in the production of APIs and drug formulations, contributing to the cardiovascular health sector.

What precautions should be taken when handling Telmisartan sodium (CAS: 515815-47-1)?

When handling Telmisartan sodium (CAS: 515815-47-1), appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn. It should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, the area should be ventilated and cleaned up using appropriate methods as outlined in the Safety Data Sheet (SDS). Avoid contact with acids and ensure proper disposal according to local regulations.