Telmisartan sodium(CAS: 515815-47-1)

Telmisartan sodium is a white or off-white crystalline powder with a molecular weight of approximately 457.71 g/mol. It is slightly soluble in water and highly soluble in sodium hydroxide solution. Telmisartan sodium is relatively stable under normal conditions but may react with acids, particularly sulfuric acid. It is widely used in pharmaceutical applications due to its hydrolytic stability.

Telmisartan sodium is synthesized through multistep organic reactions. The key steps include the coupling of an aromatic amine with a carboxylic acid followed by a condensation reaction. The process typically uses palladium catalysts and involves protecting groups to enhance selectivity and yield. The final product is obtained with a yield of approximately 70-80%.

Telmisartan sodium is primarily used in the pharmaceutical industry. It serves as a prodrug for telmisartan, which is an angiotensin II receptor antagonist used to treat hypertension and heart failure. It is also used in the production of APIs and drug formulations, contributing to the cardiovascular health sector.

When handling Telmisartan sodium (CAS: 515815-47-1), appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn. It should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, the area should be ventilated and cleaned up using appropriate methods as outlined in the Safety Data Sheet (SDS). Avoid contact with acids and ensure proper disposal according to local regulations.