(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid | CAS No. 511272-51-8

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid

Basic Information

CAS Number

511272-51-8

Molecular Formula

C24H20FNO4

Molecular Weight

405.43 g/mol

AD

Basic Physical Properties

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC(=O)O)C4=CC(=CC=C4)F

InChI

InChI=1S/C24H20FNO4/c25-16-7-5-6-15(12-16)22(13-23(27)28)26-24(29)30-14-21-19-10-3-1-8-17(19)18-9-2-4-11-20(18)21/h1-12,21-22H,13-14H2,(H,26,29)(H,27,28)/t22-/m1/s1

InChIKey

ZZERQNLGPZUNLM-JOCHJYFZSA-N

LogP

4.880200000000004

Topological Polar Surface Area

75.63000000000001 Ų

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

592

Synonyms & References

English

  • (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid
  • FMOC-(R)-3-AMINO-3-(3-FLUORO-PHENYL)-PROPIONIC ACID
  • Fmoc-(R)-3-Amino-3-(3-fluorophenyl)-propionic acid
  • FMOC-(R)-3-AMINO-3-(3-FLUOROPHENYL)PROPIONIC ACID,
  • Fmoc-D-β-Phe(3-F)-OH
  • Fmoc-3-Fluoro-D-b-phenylalanine
  • (3R)-3-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-3-(3-fluorophenyl)propanoic acid
  • fmoc-(R)-3-amino-3-(3-fluoro-phenyl)-propionic acid, AldrichCPR
  • AKOS015948930
  • AC-25390
  • (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-fluorophenyl)propanoic acid
  • CS-0181521
  • (R)-Fmoc-beta-Phe(3-F)-OH
  • 511272-51-8
  • A50476
  • Fmoc-(R)-3-Amino-3-(3-fluoro-phenyl)-propionic acid
  • (3R)-3-{[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO}-3-(3-FLUOROPHENYL)PROPANOIC ACID
  • (3R)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(3-fluorophenyl)propanoic acid
  • Fmoc-(R)-3-amino-3-(3-fluorophenyl)propionic acid
  • PS-12362
  • MFCD03428032
  • fmoc-(r)-3-amino-3-(3-fluorophenyl)propanoic acid
  • EN300-1162994
  • Fmoc-R-3-Amino-3-(3-fluorophenyl)-propionic acid
  • DTXSID80375869

MDL Number

MFCD03428032

FAQ

What are the physical and chemical properties of (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid (CAS: 511272-51-8)?

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid is a crystalline compound with a molecular weight of approximately 475.43 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and DMSO. The compound is moderately reactive, particularly in esterification reactions. It is stable under neutral and slightly acidic conditions but may decompose under strong acidic or basic conditions.

How is (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid (CAS: 511272-51-8) typically synthesized?

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid can be synthesized through multistep processes, often involving protection of the amino group, coupling reactions, and subsequent deprotection. Commonly, the synthesis involves the use of fluoren-9-yl methanol and 3-fluorophenylacetic acid. The key steps include coupling with a coupling reagent like HATU in the presence of a base such as DIPEA, followed by purification and desalting to obtain the desired compound with high yield and selectivity.

What industries use (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid (CAS: 511272-51-8)?

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid is primarily used in the pharmaceutical industry for the development of new drugs due to its bioactive properties. It is also utilized in the polymer industry for the synthesis of functional polymers and as a monomer. Additionally, it has potential applications in sensor technology and semiconductor manufacturing due to its unique chemical structure and reactivity.

What precautions should be taken when handling (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid (CAS: 511272-51-8)?

When handling (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid (CAS: 511272-51-8), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure to potentially hazardous fumes. Spills should be cleaned up immediately using appropriate materials, and the area should be thoroughly rinsed with water. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.

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