(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid

Basic Information

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CAS Number

51-35-4

Molecular Formula

C5H9NO3

Molecular Weight

131.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

273?°C (dec.)

Boiling Point

355.2°C at 760 mmHg

Water Solubility

357.8 g/L (20 o C)

Flash Point

168.6°C

Solubility

H2O: 50 mg/mL

Refractive Index

-75.5 ° (C=4, H2O)

Specific Rotation

-75.5 º (c=5, H2O)

SMILES

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O[C@H]1CN[C@@H](C1)C(=O)O

InChI

InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

InChIKey

PMMYEEVYMWASQN-DMTCNVIQSA-N

LogP

-1.2061999999999997

pKa

1.82, 9.66(at 25℃)

Topological Polar Surface Area

69.56 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

125

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Storage Conditions

2-8℃

Synonyms & References

English

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
H-HYP-OH (TRANS)
H-L-HYDROXYPROLINE
H-L-HYP-OH
H-TRANS-HYP-OH
HYDROXY-L-PROLINE
HYDROXY-L-PROLINE, TRANS-4-
L-Hydroxyproline
trans-4-Hydroxy-L-proline
(2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
4-HYDROXY-L-PROLINE TRANS ISOMER
4-Hydroxyproline
DL-TRANS-HYDROXYPROLINE
H-O-Hyp-OH
HYDROXYPROLINE, L-(RG)
L-trans-4-hydroxyproline
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid,Hyp
Dec-2t-en-4,6-diin-1-ol
dec-2t-ene-4,6-diyn-1-ol
rans-4-Hydroxy-L-proline
trans-L-4-hydroxyproline
trans-Lachnophyllol
Hyp
Hydroxyproline
H-Hyp-OH
(2S,4R)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid
4-Hydroxy-L-proline
(2S)-4-hydroxypyrrolidine-2-carboxylic acid
cis-Hydroxyproline
PMMYEEVYMWASQN-BKLSDQPFSA-N
Proline, 4-hydroxy-

MDL Number

MFCD00064320

Customs Code

2933990090

FAQ

What is (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 51-35-4)?

(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid, with CAS number 51-35-4, is a chiral organic compound containing a pyrrolidine ring with hydroxyl and carboxylic acid functional groups. It is commonly used in the synthesis of pharmaceuticals and has a molecular formula of C5H10N2O3. The compound is known for its stability and reactivity in various chemical reactions.

What are the main uses of (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 51-35-4)?

(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 51-35-4) is widely utilized in pharmaceutical research for the development of drugs targeting neurological and metabolic disorders. It also plays a role in organic synthesis as a building block for more complex molecules. Additionally, it is used in the production of certain polymers and as a chiral auxiliary in asymmetric catalysis.

Is (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 51-35-4) safe?

(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 51-35-4) is generally considered safe when handled properly. However, it may cause mild irritation to the skin and eyes. Protective measures such as gloves and safety goggles are recommended during handling. Safety data sheets should be consulted for detailed information on exposure limits and emergency procedures.

How should (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 51-35-4) be stored?

(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 51-35-4) should be stored in a cool, dry, and well-ventilated area away from light. It is typically kept in a sealed container to prevent moisture ingress. The storage temperature should be maintained between 2-8°C, and it should be protected from strong oxidizing agents to ensure stability and prolong shelf life.