3-Chloro-N-(3-hydroxyphenyl)propanamide

Basic Information

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CAS Number

50297-40-0

Molecular Formula

C9H10ClNO2

Molecular Weight

199.64 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC(=CC(=C1)O)NC(=O)CCCl

InChI

InChI=1S/C9H10ClNO2/c10-5-4-9(13)11-7-2-1-3-8(12)6-7/h1-3,6,12H,4-5H2,(H,11,13)

InChIKey

PNLKLWHMPQKCEV-UHFFFAOYSA-N

LogP

1.9595999999999996

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

175

Synonyms & References

English

3-Chloro-N-(3-hydroxyphenyl)propanamide
Propanamide, 3-chloro-N-(3-hydroxyphenyl)-
3-chloro-N-(3-hydroxyphenyl)propanamide(SALTDATA: FREE)
3-chloro-propionic acid-(3-hydroxy-anilide)
3-Chlor-propionsaeure-(3-hydroxy-anilid)
AG-F-68938
Ambcb6018839
CTK4J2412
SureCN4188909
β-Chlor-propionsaeure-(3-oxy-anilid)
CHEMBRDG-BB 6018839
3-CHLORO-N-(3-HYDROXYPHENYL)PROPANAMIDE
SCHEMBL4188909
DTXSID20598095
AKOS010502115
3-chloro-N-(3-hydroxy-phenyl)-propanamide
50297-40-0
CS-0313180
MFCD02812236
N4S3K5QAU5
3-Chloro-N-(3-hydroxyphenyl)propionamide
AC-33619
AS-31350
3-chloro-N-(3-hydroxy phenyl)propanamide
PNLKLWHMPQKCEV-UHFFFAOYSA-N
DB-099202
beta-Chloro-m-hydroxypropionanilide

MDL Number

MFCD02812236

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 3-Chloro-N-(3-hydroxyphenyl)propanamide (CAS: 50297-40-0)?

3-Chloro-N-(3-hydroxyphenyl)propanamide is a white crystalline solid with a molecular weight of approximately 222.6 g/mol. It has a solubility of about 3 g/L in water and is slightly soluble in ethanol. It shows moderate reactivity towards nucleophiles and is stable under normal conditions but can undergo hydrolysis over extended periods.

How is 3-Chloro-N-(3-hydroxyphenyl)propanamide (CAS: 50297-40-0) typically synthesized?

3-Chloro-N-(3-hydroxyphenyl)propanamide is typically synthesized through a condensation reaction between 3-chloroisocyanatophenyl acetic acid and hydroxybenzaldehyde, using a mild base like triethylamine as a catalyst. The process involves heating the mixture to promote the reaction, which yields a high product selectivity and a moderate yield of up to 85%.

What industries use 3-Chloro-N-(3-hydroxyphenyl)propanamide (CAS: 50297-40-0)?

3-Chloro-N-(3-hydroxyphenyl)propanamide is used in the pharmaceutical industry for the synthesis of certain drug intermediates due to its aromatic and functional groups. It is also utilized in the polymer industry for modifying polymer properties and in the chemical sensor sector for developing sensors with specific reactivity towards organic compounds.

What precautions should be taken when handling 3-Chloro-N-(3-hydroxyphenyl)propanamide (CAS: 50297-40-0)?

When handling 3-Chloro-N-(3-hydroxyphenyl)propanamide, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a well-ventilated area away from heat sources and incompatible materials. In case of spill, it should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.