3-Chloro-N-(3-hydroxyphenyl)propanamide(CAS: 50297-40-0)

3-Chloro-N-(3-hydroxyphenyl)propanamide is a white crystalline solid with a molecular weight of approximately 222.6 g/mol. It has a solubility of about 3 g/L in water and is slightly soluble in ethanol. It shows moderate reactivity towards nucleophiles and is stable under normal conditions but can undergo hydrolysis over extended periods.

3-Chloro-N-(3-hydroxyphenyl)propanamide is typically synthesized through a condensation reaction between 3-chloroisocyanatophenyl acetic acid and hydroxybenzaldehyde, using a mild base like triethylamine as a catalyst. The process involves heating the mixture to promote the reaction, which yields a high product selectivity and a moderate yield of up to 85%.

3-Chloro-N-(3-hydroxyphenyl)propanamide is used in the pharmaceutical industry for the synthesis of certain drug intermediates due to its aromatic and functional groups. It is also utilized in the polymer industry for modifying polymer properties and in the chemical sensor sector for developing sensors with specific reactivity towards organic compounds.

When handling 3-Chloro-N-(3-hydroxyphenyl)propanamide, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a well-ventilated area away from heat sources and incompatible materials. In case of spill, it should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.