2-Bromo-1-(2-chlorophenyl)ethanone

Basic Information

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CAS Number

5000-66-8

Molecular Formula

C8H6BrClO

Molecular Weight

233.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

162-166 ºC (20 MMHG)

Boiling Point

105 °C/1 mmHg

Refractive Index

n20/D 1.590(lit.)

SMILES

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C1=CC=C(C(=C1)C(=O)CBr)Cl

InChI

InChI=1S/C8H6BrClO/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4H,5H2

InChIKey

WZWWEVCLPKAQTA-UHFFFAOYSA-N

LogP

2.917600000000001

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

149

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Lachrymatory

Synonyms & References

English

1Y-0714
2'-Chlorophenacyl bromide
2-Bromo-1-(2-chlorophenyl)-1-ethanone
AM20040572
o-Chlorophenacyl bromide
FT-0611329
2-CHLORO-2'-BROMOACETOPHENONE
2'-Chloro-2-bromoacetophenone
2-Bromo-2 inverted exclamation mark -chloroacetophenone
SCHEMBL38141
F0001-1306
J-508137
2-chlorophenacylbromide
DTXSID30370945
Acetophenone, 2-bromo-2'-chloro-
2-bromo-1-(chloro-phenyl)-ethanone
2-bromo-1-(2-chlorophenyl)ethan-1-one
AKOS000210546
2-chlorophenacyl bromide
EN300-20758
MFCD00832993
2-Bromo-2'-chloroacetophenone
P72V4K6QZC
2-chloro phenacylbromide
2-bromo-1-(2-chloro-phenyl)-ethanone
A7434
NS00126534
2-bromo-2'-chloro acetophenone
SY004173
2-Bromo-2'-chloroacetophenone, 95%
BROMOMETHYL 2-CHLOROPHENYL KETONE

MDL Number

MFCD00832993

Customs Code

2914700090

FAQ

What are the physical and chemical properties of 2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8)?

2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8) is a white crystalline solid with a molecular weight of approximately 230.02 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly with nucleophiles. It is stable under standard storage conditions but requires protection from light and moisture.

How is 2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8) typically synthesized?

2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8) is typically synthesized via a bromination reaction of 1-(2-chlorophenyl)ethanone with bromine in the presence of a catalyst such as iron(III) bromide. The reaction involves the introduction of a bromine atom at the alpha position of the ketone, yielding the desired compound with a yield of around 75-80%.

What industries use 2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8)?

2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8) is used in the pharmaceutical industry for the synthesis of certain drug intermediates and in the chemical industry for the development of organic compounds. It is also utilized in the production of certain dyes and as a reagent in organic synthesis. Its applications in polymers and semiconductors are less common but may be explored for specific properties.

What precautions should be taken when handling 2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8)?

When handling 2-Bromo-1-(2-chlorophenyl)ethanone (CAS: 5000-66-8), use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a fume hood to minimize exposure to vapors. Ensure proper ventilation and avoid contact with water and moisture. In case of a spill, immediately clean it up with appropriate absorbent materials and dispose of the waste according to local regulations. Refer to the safety data sheet (SDS) for detailed handling and disposal information.