Pazopanib | CAS No. 444731-52-6

Pazopanib

Basic Information

View in Editor

CAS Number

444731-52-6

Molecular Formula

C21H23N7O2S

Molecular Weight

437.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

281-291°C

Boiling Point

728.8±70.0°C at 760 mmHg

Flash Point

359℃

SMILES

View in Editor

CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N

InChI

InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)

InChIKey

CUIHSIWYWATEQL-UHFFFAOYSA-N

LogP

3.1390400000000005

Topological Polar Surface Area

119.03 Å²

Hydrogen Bond Donor/Acceptor

3 / 9

Complexity

717

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Pazopanib
BCP01839
Tox21_113174_1
7RN5DR86CK
Pazopanib (free base)
SB17290
NCGC00188865-02
cid_10113978
Pazopanib [INN]
PAZOPANIB [VANDF]
HMS3745G05
PAZOPANIB [EMA EPAR]
GW-780604
Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-
NCGC00188865-03
AB01273967_05
AB01273967-02
HMS3244C21
FT-0659928
AM20090659
GW 78603
5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide
Q-101400
FT-0684794
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide
HSDB 8210
AC-8522
5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide
Pazopanib- Bio-X
BDBM26474
CHEBI:71219

MDL Number

MFCD11616589

FAQ

What is Pazopanib (CAS: 444731-52-6)?

Pazopanib is a pharmaceutical compound with the CAS number 444731-52-6. It is a multi-kinase inhibitor used primarily in cancer treatment. Its chemical formula is C24H24N4O5S, and it is a white to off-white solid with good solubility in DMSO and methanol. Pazopanib is known for its ability to target various receptors involved in tumor growth and angiogenesis.

What are the main uses of Pazopanib (CAS: 444731-52-6)?

Pazopanib is mainly used in the treatment of advanced renal cell carcinoma and certain types of soft tissue sarcoma. It is also being researched for potential applications in other cancers, including breast, lung, and pancreatic cancer. As a kinase inhibitor, it is effective in blocking the signals that promote cancer cell proliferation and blood vessel formation, making it a valuable drug in oncology.

Is Pazopanib (CAS: 444731-52-6) safe?

Pazopanib is generally considered safe when used as prescribed, but it may cause side effects such as fatigue, diarrhea, and hypertension. It is important to follow safety guidelines and consult healthcare professionals for proper handling. Safety standards are in place to ensure its use in controlled medical settings, and protective measures should be taken during storage and transportation to prevent exposure.

How should Pazopanib (CAS: 444731-52-6) be stored?

Pazopanib should be stored in a cool, dry place away from light. It is typically maintained at a temperature between 15°C to 25°C (59°F to 77°F) and should be kept in a sealed container to prevent moisture ingress. Proper storage ensures its stability and maintains potency, which is crucial for pharmaceutical quality and effectiveness.