Ethyl 2-amino-4-methyl-3-thiophenecarboxylate

Basic Information

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CAS Number

43088-42-2

Molecular Formula

C8H11NO2S

Molecular Weight

185.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

79.0 to 83.0 deg-C

Boiling Point

279 ºC

Flash Point

123 ºC

Refractive Index

1.573

SMILES

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CCOC(=O)C1=C(SC=C1C)N

InChI

InChI=1S/C8H11NO2S/c1-3-11-8(10)6-5(2)4-12-7(6)9/h4H,3,9H2,1-2H3

InChIKey

ILYCZKOBLRJJSW-UHFFFAOYSA-N

LogP

1.81542

Topological Polar Surface Area

52.32 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

174

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

Benzo[c]cinnolineN-oxide
FS-1651
2-Amino-4-methylthiophene-3-carboxylic acid ethyl ester
3-Thiophenecarboxylic acid, 2-amino-4-methyl-, ethyl ester
AKOS000100024
43088-42-2
Z104476356
ethyl 2-amino4-methylthiophene-3-carboxylate
SCHEMBL162443
SY020317
E1103
2-amino-4-methyl-3-ethoxycarbonyl-thiophene
ETHYL 2-AMINO-4-METHYLTHIOPHENE 3-CARBOXYLATE
CS-W008036
Ethyl 2-amino-4-methyl-3-thiophenecarboxylate
Ethyl 2-amino-4-methyl-3-thiophenecarboxylate #
DTXSID00334559
2-Amino-3-(ethoxycarbonyl)-4-methylthiophene
3-Thiophenecarboxylicacid,2-amino-4-methyl-,ethyl ester
BB 0217138
Ethyl 2-amino-4-methylthiophene-3-carboxylate
Maybridge1_003755
AC-28067
FT-0625927
HMS552C15
2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester
MFCD00051669
GK 00116
EN300-20006
Ethyl 2-amino-4-methyl-thiophene-3-carboxylate
AM803901

MDL Number

MFCD00051669

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2)?

Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2) is a crystalline solid with a molecular weight of approximately 214.27 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and methanol. The compound is relatively stable, but reactive towards strong bases. It has a thiophene derivative ring, making it susceptible to nucleophilic substitution reactions.

How is Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2) typically synthesized?

Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2) is commonly synthesized through an amidation reaction of 4-methyl-3-thiophenecarboxylic acid and ethyl amine. The reaction proceeds efficiently at room temperature using anhydrous conditions. Catalysts such as triethylamine or dicyclohexylcarbodiimide (DCC) are often employed to increase yield and selectivity.

What industries use Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2)?

Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2) is utilized in several industries. It is a key intermediate in the production of pharmaceuticals, particularly in the synthesis of anticancer drugs. Additionally, it finds applications in the development of sensors and semiconductors due to its unique chemical structure and reactivity.

What precautions should be taken when handling Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2)?

When handling Ethyl 2-amino-4-methyl-3-thiophenecarboxylate (CAS: 43088-42-2), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a fume hood due to its potential reactivity. Spills should be cleaned up with caution using absorbent materials and proper disposal methods. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.