1-(2-Chloroethoxy)propane

Basic Information

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CAS Number

42149-74-6

Molecular Formula

C5H11ClO

Molecular Weight

122.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Melting Point

-60 ºC

Boiling Point

129°C

Water Solubility

6.2 g/L (20 ºC)

Flash Point

28 ºC

Refractive Index

1.4157-1.4177

SMILES

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CCCOCCCl

InChI

InChI=1S/C5H11ClO/c1-2-4-7-5-3-6/h2-5H2,1H3

InChIKey

BHDSGQOSIWVMJW-UHFFFAOYSA-N

LogP

1.6518

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

31.3

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

H10822
FT-0613235
NS00031113
SCHEMBL680603
C1174
DTXSID90194982
2-Propoxyethyl chloride
CS-0200392
2-propyloxyethyl chloride
A825789
2-chloroethylpropyl ether
1-(2-Chloroethoxy)propane
2-chloroethyl n-propyl ether, AldrichCPR
AKOS009156555
1-(2-Chloroethoxy)propane #
2-chloroethyl-n-propyl ether
MFCD00059052
2-chloroethyl n-propyl ether
EN300-95114
2-Chloroethyl-n-propylether
EINECS 255-685-0
BS-32420
2-Chloroethyl Propyl Ether
chloroethoxypropane
42149-74-6
Propane, 1-(2-chloroethoxy)-
2-chloroethylpropylether
n-Propoxyethylchloride
1-chloro-2-propoxyethane
2-Propoxyethyl Chloride

MDL Number

MFCD00059052

Customs Code

2909199090

FAQ

What are the physical and chemical properties of 1-(2-Chloroethoxy)propane (CAS: 42149-74-6)?

1-(2-Chloroethoxy)propane (CAS: 42149-74-6) is a colorless liquid with a molecular weight of approximately 133.55 g/mol. It has a low boiling point of 73-74°C and is moderately soluble in water. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It has low viscosity and good solubility in organic solvents like ethanol and acetone.

How is 1-(2-Chloroethoxy)propane (CAS: 42149-74-6) typically synthesized?

1-(2-Chloroethoxy)propane (CAS: 42149-74-6) is synthesized by reacting 1-chloropropane with ethylene oxide in the presence of a catalyst such as sodium hydroxide. The reaction is typically conducted at room temperature, and the yield is moderate, around 70-80%. The use of a phase transfer catalyst can enhance the reaction selectivity and yield.

What industries use 1-(2-Chloroethoxy)propane (CAS: 42149-74-6)?

1-(2-Chloroethoxy)propane (CAS: 42149-74-6) is used in various industries. It is a key intermediate in the production of pharmaceuticals, where it serves as a building block for synthesizing complex organic molecules. It is also used in the polymer industry for the preparation of polyurethane and in the semiconductor industry for the development of chemically amplified resists.

What precautions should be taken when handling 1-(2-Chloroethoxy)propane (CAS: 42149-74-6)?

When handling 1-(2-Chloroethoxy)propane (CAS: 42149-74-6), proper personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or fume hood to prevent inhalation of vapors. In case of spill, the area should be evacuated immediately and the spill cleaned up using appropriate absorbents. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.