2-Bromo-4-(4-fluorophenyl)-1,3-thiazole

Basic Information

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CAS Number

412923-44-5

Molecular Formula

C9H5BrFNS

Molecular Weight

258.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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Fc1ccc(cc1)c2csc(Br)n2

InChI

InChI=1S/C9H5BrFNS/c10-9-12-8(5-13-9)6-1-3-7(11)4-2-6/h1-5H

InChIKey

GSCFEPBWOIFTNA-UHFFFAOYSA-N

LogP

3.7117000000000004

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Synonyms & References

English

2-BROMO-4-(4-FLUORO-PHENYL)-THIAZOLE
2-Bromo-4-(4-fluorophenyl)-1,3-thiazole
2-bromo-4-(4-fluorophenyl)thiazole
BB_SC-7644
CTK8I6621
SBB077213
STK933922
SureCN3761118

MDL Number

MFCD07375244

FAQ

What are the physical and chemical properties of 2-Bromo-4-(4-fluorophenyl)-1,3-thiazole (CAS: 412923-44-5)?

2-Bromo-4-(4-fluorophenyl)-1,3-thiazole is a crystalline solid with a molecular weight of approximately 279.11 g/mol. It has a low water solubility and is slightly soluble in common organic solvents. This thiazole derivative is known for its good reactivity in nucleophilic substitution reactions and aromatic substitution reactions.

How is 2-Bromo-4-(4-fluorophenyl)-1,3-thiazole (CAS: 412923-44-5) typically synthesized?

2-Bromo-4-(4-fluorophenyl)-1,3-thiazole is typically synthesized via a multistep process involving bromination of 4-(4-fluorophenyl)-1,3-thiazole. Commonly, this involves using bromine in the presence of a Lewis acid catalyst like aluminum chloride. The reaction is carried out in an organic solvent, and purification is achieved by recrystallization.

What industries use 2-Bromo-4-(4-fluorophenyl)-1,3-thiazole (CAS: 412923-44-5)?

2-Bromo-4-(4-fluorophenyl)-1,3-thiazole is used in various industries, particularly in the pharmaceutical sector for its potential as an intermediate in drug synthesis. It also has applications in the polymer and sensor fields, where its chemical properties make it suitable for functionalization and modification of materials.

What precautions should be taken when handling 2-Bromo-4-(4-fluorophenyl)-1,3-thiazole (CAS: 412923-44-5)?

When handling 2-Bromo-4-(4-fluorophenyl)-1,3-thiazole, it is important to use appropriate personal protective equipment (PPE), including gloves and laboratory coats. Work should be conducted in a well-ventilated fume hood to minimize exposure to vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety information.