5-Chloro-2,3-diphenylpyrazine

Basic Information

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CAS Number

41270-66-0

Molecular Formula

C16H11ClN2

Molecular Weight

266.73 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

125.0 to 129.0 deg-C

Boiling Point

145°C/0.001mmHg

SMILES

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C1=CC=C(C=C1)C2=NC=C(N=C2C3=CC=CC=C3)Cl

InChI

InChI=1S/C16H11ClN2/c17-14-11-18-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-11H

InChIKey

VUGNCPVAXWZTOL-UHFFFAOYSA-N

LogP

4.464000000000003

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

272

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

5-Chloro-2,3-diphenylpyrazine
2-Chloro-5,6-diphenylpyrazine
2,3-diphenyl-5-chloropyrazine
AK123563
C16H11ClN2
VUGNCPVAXWZTOL-UHFFFAOYSA-N
BCP14488
5680AB
CM10656
AS06571
SY055821
AX8247741
ST24044593
MFCD00234892
41270-66-0
C3205
5-Chloro-2 pound not3-diphenylpyrazine
DTXSID40394713
CS-M3068
SCHEMBL383762
AKOS016011827
AC-29196
AMY243
AC-907/25005304
5-chloro-2,3-diphenylpyrazine
DS-7038

MDL Number

MFCD00234892

FAQ

What are the physical and chemical properties of 5-Chloro-2,3-diphenylpyrazine (CAS: 41270-66-0)?

5-Chloro-2,3-diphenylpyrazine is a solid with a crystalline form. Its molecular weight is approximately 313.77 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and dichloromethane. The compound is relatively stable under normal conditions but can react with strong acids and bases. It is less reactive towards electrophiles but can undergo substitution reactions under appropriate conditions.

How is 5-Chloro-2,3-diphenylpyrazine (CAS: 41270-66-0) typically synthesized?

5-Chloro-2,3-diphenylpyrazine is typically synthesized through a multi-step process involving the coupling of a phenyl chloro compound with an aryl hydrazine. The reaction is catalyzed by palladium and is carried out in the presence of a base. The selectivity and yield of the reaction can be enhanced by optimizing the reaction conditions, such as temperature and solvent choice.

What industries use 5-Chloro-2,3-diphenylpyrazine (CAS: 41270-66-0)?

5-Chloro-2,3-diphenylpyrazine is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a crosslinking agent and in the development of sensors and semiconductors due to its electronic properties.

What precautions should be taken when handling 5-Chloro-2,3-diphenylpyrazine (CAS: 41270-66-0)?

When handling 5-Chloro-2,3-diphenylpyrazine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult a safety data sheet (SDS) for detailed handling and disposal information.