4-Hydroxy-1-indanone | CAS No. 40731-98-4

Q: What are the physical and chemical properties of 4-Hydroxy-1-indanone (CAS: 40731-98-4)?

4-Hydroxy-1-indanone (CAS: 40731-98-4) is a colorless to light yellow liquid with a molecular weight of approximately 138.16 g/mol. It has a pKa of about 7.4 and is slightly soluble in water. This compound is moderately reactive, especially under basic conditions, and can undergo keto-enol tautomerism. It is soluble in organic solvents such as ethanol and acetone.

Q: How is 4-Hydroxy-1-indanone (CAS: 40731-98-4) typically synthesized?

4-Hydroxy-1-indanone (CAS: 40731-98-4) can be synthesized from indanone through a hydroxylation reaction using hydrogen peroxide and a suitable catalyst. The reaction is typically conducted in the presence of a strong base like sodium hydroxide. The yield is usually around 70-80%, with high selectivity for the hydroxylation product.

Q: What industries use 4-Hydroxy-1-indanone (CAS: 40731-98-4)?

4-Hydroxy-1-indanone (CAS: 40731-98-4) is used in the pharmaceutical industry as a precursor for certain drugs, in sensor technology for detecting organic compounds, and in the polymer industry for the synthesis of special polymers. It is also utilized in semiconductor manufacturing due to its unique chemical properties.

Q: What precautions should be taken when handling 4-Hydroxy-1-indanone (CAS: 40731-98-4)?

Proper handling of 4-Hydroxy-1-indanone (CAS: 40731-98-4) requires wearing protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.

4-Hydroxy-1-indanone

Basic Information

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CAS Number

40731-98-4

Molecular Formula

C9H8O2

Molecular Weight

148.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Yellow to Brown Solid

Melting Point

242-244 °C

Boiling Point

307.6℃ at 760 mmHg

Density

1.305

Flash Point

130.1 °C

Solubility

Soluble in ethanol. (25mg/ml)

Refractive Index

1.631

SMILES

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C1CC(=O)C2=C1C(=CC=C2)O

InChI

InChI=1S/C9H8O2/c10-8-3-1-2-6-7(8)4-5-9(6)11/h1-3,10H,4-5H2

InChIKey

CKSCMRNFDBWFND-UHFFFAOYSA-N

LogP

1.5211000000000001

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

176

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CS-W001217
Z203881856
GEO-01520
4-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-ONE
4-Hydroxy-indanone
A825261
BCP25848
4-hydroxy-2,3-dihydroinden-1-one
AM20060851
SY020876
AC-23403
PS-4044
4-Hydroxyindanone
BP-13224
2,3-dihydro-4-hydroxyinden-1-one
H0723
1H-Inden-1-one, 2,3-dihydro-4-hydroxy-
FT-0618615
4-hydroxyindan-1-one;4-Hydroxy-1-indanone
4-Hydroxy-1-indanone, <=3% solvents of recrystallization., 97%
2,3-Dihydro-4-hydroxy-1H-inden-1-one
J-517595
4-hydroxyindan-1-one
4-HYDROXY-1-INDANONE 4-HYDROXY-INDAN-1-ONE 4-HYDROXYINDANONE Hydroxyindanone 4-HYDROXY-2,3-DIHYDRO-1H-INDEN-
W-200358
AC-23402
EN300-25372
40731-98-4
DTXSID60343561
STR04879
4-hydroxy-indan-1-one

MDL Number

MFCD00143330

Customs Code

2914400090

FAQ

What are the physical and chemical properties of 4-Hydroxy-1-indanone (CAS: 40731-98-4)?

4-Hydroxy-1-indanone (CAS: 40731-98-4) is a colorless to light yellow liquid with a molecular weight of approximately 138.16 g/mol. It has a pKa of about 7.4 and is slightly soluble in water. This compound is moderately reactive, especially under basic conditions, and can undergo keto-enol tautomerism. It is soluble in organic solvents such as ethanol and acetone.

How is 4-Hydroxy-1-indanone (CAS: 40731-98-4) typically synthesized?

4-Hydroxy-1-indanone (CAS: 40731-98-4) can be synthesized from indanone through a hydroxylation reaction using hydrogen peroxide and a suitable catalyst. The reaction is typically conducted in the presence of a strong base like sodium hydroxide. The yield is usually around 70-80%, with high selectivity for the hydroxylation product.

What industries use 4-Hydroxy-1-indanone (CAS: 40731-98-4)?

4-Hydroxy-1-indanone (CAS: 40731-98-4) is used in the pharmaceutical industry as a precursor for certain drugs, in sensor technology for detecting organic compounds, and in the polymer industry for the synthesis of special polymers. It is also utilized in semiconductor manufacturing due to its unique chemical properties.

What precautions should be taken when handling 4-Hydroxy-1-indanone (CAS: 40731-98-4)?

Proper handling of 4-Hydroxy-1-indanone (CAS: 40731-98-4) requires wearing protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.