1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane

Basic Information

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CAS Number

406-78-0

Molecular Formula

C4H3F7O

Molecular Weight

200.05 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Basic Physical Properties

Boiling Point

56°C

Refractive Index

1.276

SMILES

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C(C(F)(F)F)OC(C(F)F)(F)F

InChI

InChI=1S/C4H3F7O/c5-2(6)4(10,11)12-1-3(7,8)9/h2H,1H2

InChIKey

CWIFAKBLLXGZIC-UHFFFAOYSA-N

LogP

2.4232000000000005

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

139

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

1,1,2,2,5,5,5-heptafluoro-3-oxapentane
1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane
MFCD00236118
406-78-0
Ethane, 1,1,2,2-tetrafluoro-1-(2,2,2-trifluoroethoxy)-
(1H,1H-Perfluoroethyl)(2H-perfluoroethyl)ether
A825230
AKOS005064051
D92655
LS-12973
SCHEMBL661236
Ethane, tetrafluoro(trifluoroethoxy)-
1,1,2,2-Tetrafluoroethyl-2,2,2-trifluoroethyl ether
T3057
Ethane,1,1,2,2-tetrafluoro-1-(2,2,2-trifluoroethoxy)-
1,1,2,2-Tetrafluoroethyl-2,2,2-trifluoroethylether
NS00019058
1,1,2,2-tetrafluoro-1-(2,2,2-trifluoroethoxy) ethane
C4H3F7O
1,1,2,2-Tetrafluoroethyl 2,2,2-trifluoroethyl ether/HFE347
DTXSID8074786
CF3CH2OCF2CF2H
Tftfe-ethane
HFE-347pcf2
1,1,2,2-tetrafluoroethyl 2,2,2-trifluoroethyl ether
HFE-347pc-f2
FT-0605966
AMY6882
2,2,2-trifluoroethyl 1,1,2,2-tetrafluoroethyl ether
1,1,1,4,4,5,5-Heptafluoro-3-oxopentane
1,1,2,2-tetrafluoroethyl2,2,2-trifluoroethyl ether

MDL Number

MFCD00236118

Customs Code

2909199090

FAQ

What are the physical and chemical properties of 1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0)?

1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0) is a colorless, odorless, and dense liquid with a high boiling point. It has a molecular weight of approximately 320.9 g/mol and a low solubility in water. The compound is highly reactive towards strong bases and nucleophiles. It is stable under normal conditions but requires storage in a dry and cool place away from direct sunlight.

How is 1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0) typically synthesized?

1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0) is synthesized via a multistep process involving fluorination reactions. Commonly, a trifluoroethanol derivative is reacted with a fluorinating agent such as N,N-dimethylformamidine or sodium bis(trimethylsilyl)amide. The reaction typically requires a catalyst and is conducted in an anhydrous solvent. The yield and selectivity can be influenced by the choice of solvent and reaction conditions.

What industries use 1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0)?

1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0) is used in various industries, including pharmaceuticals for formulation and drug delivery systems, polymers for specialty applications, sensors for detection, and semiconductors for cleaning and etching processes. Its unique chemical properties make it valuable in these sectors for its stability and reactivity.

What precautions should be taken when handling 1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0)?

When handling 1,1,2,2-Tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane (CAS: 406-78-0), wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Ensure the work area is well-ventilated, and use a fume hood. Store the compound in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, use appropriate spill kits and follow the safety data sheet (SDS) for cleanup instructions.