4-Fluorobenzoyl chloride

Basic Information

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CAS Number

403-43-0

Molecular Formula

C7H4ClFO

Molecular Weight

158.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

10-12 °C

Boiling Point

82 °C/20 mmHg

Water Solubility

Reacts with water.

Refractive Index

n20/D 1.532(lit.)

SMILES

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C1=CC(=CC=C1C(=O)Cl)F

InChI

InChI=1S/C7H4ClFO/c8-7(10)5-1-3-6(9)4-2-5/h1-4H

InChIKey

CZKLEJHVLCMVQR-UHFFFAOYSA-N

LogP

2.2047

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

130

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Lachrymatory

Synonyms & References

English

4-flurobenzoyl chloride
A25256
4-fluoro benzoylchloride
4-fluoranylbenzoyl chloride
WW9JD3YJ9Q
p-Fluorobenzoic acid chloride
InChI=1/C7H4ClFO/c8-7(10)5-1-3-6(9)4-2-5/h1-4H
4-fluorobenzoic chloride
p-fluorobenzoyl choride
4-Fluorobenzenecarbonyl chloride
UNII-WW9JD3YJ9Q
DTXSID5059953
4-fluoro-1-benzenecarbonyl chloride
A825063
4-fluorobenzoylchloride
4-Fluorobenzoyl chloride
4-fluoro-phenyl carboxylic acid chloride
PB42763
4-fluorobenzene carbonyl chloride
p-Fluorobenzoyl chloride
1071809-52-3
p-fluorobenzoylchloride
CZKLEJHVLCMVQR-UHFFFAOYSA-
4-Fluoro benzoyl chloride
AMY202100080
4-fluoro-benzoyl chloride
AKOS000268647
4-Fluorobenzoyl chloride, 98%
4-fluorobenzoyl-chloride
CK1093
EINECS 206-961-4

MDL Number

MFCD00000684

Customs Code

29163900

FAQ

What is 4-Fluorobenzoyl chloride (CAS: 403-43-0)?

4-Fluorobenzoyl chloride is an aromatic acyl chloride compound with the chemical formula C8H6ClFO2. It features a fluorine atom at the para position on a benzoyl chloride group, making it reactive and useful in organic synthesis. This compound is a colorless liquid with a sharp odor, highly soluble in organic solvents, and sensitive to moisture and light.

What are the main uses of 4-Fluorobenzoyl chloride (CAS: 403-43-0)?

4-Fluorobenzoyl chloride is primarily used in pharmaceuticals for synthesizing fluorinated drugs and intermediates. It also serves in industrial applications such as polymer production and dye manufacturing. In research, it acts as an acylating agent for creating fluorine-containing compounds, including agrochemicals and organic materials.

Is 4-Fluorobenzoyl chloride (CAS: 403-43-0) safe?

4-Fluorobenzoyl chloride is toxic and requires careful handling. It may cause skin and eye irritation, respiratory issues, and is harmful if ingested. Safety measures include wearing protective gloves, goggles, and a lab coat, using fume hoods, and adhering to OSHA and EPA guidelines. Always follow proper disposal protocols to minimize environmental impact.

How should 4-Fluorobenzoyl chloride (CAS: 403-43-0) be stored?

4-Fluorobenzoyl chloride should be stored in a cool, dry place (ideally 2-8°C), sealed in airtight containers to prevent moisture and contamination. It must be kept away from light and incompatible materials. Storage in a well-ventilated area is essential, and it is recommended to use a fume hood to ensure stability and safety.