3-Fluoroisonicotinaldehyde

Basic Information

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CAS Number

40273-47-0

Molecular Formula

C6H4FNO

Molecular Weight

125.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

70 °C/25 mmHg

Refractive Index

n20/D 1.5170(lit.)

SMILES

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C1=CN=CC(=C1C=O)F

InChI

InChI=1S/C6H4FNO/c7-6-3-8-2-1-5(6)4-9/h1-4H

InChIKey

KLKQXQXSZCNWLZ-UHFFFAOYSA-N

LogP

1.0332

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

107

Safety Information

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GHS Hazard Pictograms

H302

H315

H317

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SY031229
3-fluoro-pyridine-4-carboxaldehyde
C6H4FNO
3-Fluoro-4-pyridinecarbaldehyde, 97%
PS-9209
A6740
DTXSID80376654
EN300-171195
3-fluoropyridine-4-carboxaldehyde
MFCD06410686
J-512563
4-Pyridinecarboxaldehyde, 3-fluoro-
AC-23842
3-fluoro-pyridine-4-carbaldehyde
CS-W016568
AKOS005259905
PB32422
3-Fluoro-4-pyridinecarboxaldehyde
3-Fluoroisonicotinaldehyde
3-fluoropyridine-4-carbaldehyde
AM20080701
Z1203162407
FT-0658429
3-fluoro-4-formylpyridine
SCHEMBL115514
KLKQXQXSZCNWLZ-UHFFFAOYSA-N
3-FLUORO-4-PYRIDINECARBALDEHYDE
40273-47-0
3-Fluoro-4-pyridinecarbaldehyde
3-FLUORO-4-FORMYLPYRIDINE
3-Fluoropyridin-4-ylcarboxaldehyde

MDL Number

MFCD06410686

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Fluoroisonicotinaldehyde (CAS: 40273-47-0)?

3-Fluoroisonicotinaldehyde is a crystalline solid with a molecular weight of approximately 161.06 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it exhibits typical aldehyde reactivity, including oxidation and reduction reactions. It is also known for its stability under standard storage conditions but may react with basic compounds.

How is 3-Fluoroisonicotinaldehyde (CAS: 40273-47-0) typically synthesized?

3-Fluoroisonicotinaldehyde can be synthesized by reacting isonicotinoyl chloride with fluoroamine in the presence of a catalytic amount of an acid like sulfuric acid. The reaction is carried out at room temperature, and the yield can be up to 80%. The product is then purified by recrystallization from an appropriate solvent.

What industries use 3-Fluoroisonicotinaldehyde (CAS: 40273-47-0)?

3-Fluoroisonicotinaldehyde is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for modifying the properties of polymers and in the semiconductor industry for manufacturing electronic materials.

What precautions should be taken when handling 3-Fluoroisonicotinaldehyde (CAS: 40273-47-0)?

When handling 3-Fluoroisonicotinaldehyde, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety glasses. This compound should be stored in a well-ventilated area away from heat sources and basic substances. In case of spills, they should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, always refer to the Safety Data Sheet (SDS).