3-Fluoroisonicotinaldehyde(CAS: 40273-47-0)

3-Fluoroisonicotinaldehyde is a crystalline solid with a molecular weight of approximately 161.06 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it exhibits typical aldehyde reactivity, including oxidation and reduction reactions. It is also known for its stability under standard storage conditions but may react with basic compounds.

3-Fluoroisonicotinaldehyde can be synthesized by reacting isonicotinoyl chloride with fluoroamine in the presence of a catalytic amount of an acid like sulfuric acid. The reaction is carried out at room temperature, and the yield can be up to 80%. The product is then purified by recrystallization from an appropriate solvent.

3-Fluoroisonicotinaldehyde is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for modifying the properties of polymers and in the semiconductor industry for manufacturing electronic materials.

When handling 3-Fluoroisonicotinaldehyde, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety glasses. This compound should be stored in a well-ventilated area away from heat sources and basic substances. In case of spills, they should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, always refer to the Safety Data Sheet (SDS).