4-Fluoro-1,2-dimethoxybenzene

Basic Information

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CAS Number

398-62-9

Molecular Formula

C8H9FO2

Molecular Weight

156.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

123°C/45mmHg

Water Solubility

Soluble in water 0.079 g/L 25°C.

Flash Point

92 ºC

Refractive Index

1.51

SMILES

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COC1=C(C=C(C=C1)F)OC

InChI

InChI=1S/C8H9FO2/c1-10-7-4-3-6(9)5-8(7)11-2/h3-5H,1-2H3

InChIKey

DAGKHJDZYJFWSO-UHFFFAOYSA-N

LogP

1.8428999999999998

Topological Polar Surface Area

18.46 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

119

Safety Information

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GHS Hazard Pictograms

H227

Hazard Statement

H227 Combustible liquid
Flammable liquids

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

J-503826
4-Fluoro-1,2-dimethoxybenzene #
4-Fluoro-1 pound not2-dimethoxybenzene
Fluorobenzene, 3,4-methoxy-
4-Fluoro-1,2-dimethoxybenzene
4-Fluoro-2-methoxyphenol, methyl ether
Benzene, 4-fluoro-1,2-dimethoxy-
A18733
1,2-Dimethoxy-4-fluorobenzene
F0385
SY046523
398-62-9
4-Fluoroveratrole
PS-8835
SCHEMBL166380
CK1196
FT-0618569
EN300-21611
AKOS000121273
4-Fluoro-1,2-dimethoxybenzene, 98%
CS-W004941
DTXSID20343981
3,4-dimethoxyfluorobenzene
MFCD00012201
AM82990
4-Fluoro-1,2-dimethoxy-Benzene
3,4-Dimethoxy-1-fluorobenzene
3,4-Dimethoxyfluorobenzene
1-fluoro-3,4-dimethoxybenzene
DAGKHJDZYJFWSO-UHFFFAOYSA-N
4-fluoroveratrol

MDL Number

MFCD00012201

Customs Code

2909309090

FAQ

What are the physical and chemical properties of 4-Fluoro-1,2-dimethoxybenzene (CAS: 398-62-9)?

4-Fluoro-1,2-dimethoxybenzene is a colorless or light yellow liquid with a molecular weight of 183.16 g/mol. It has a density of 1.09 g/cm³ and a boiling point of 209-211°C. This compound is slightly soluble in water but miscible with common organic solvents. It is reactive towards strong acids and bases, and it undergoes electrophilic aromatic substitution reactions readily.

How is 4-Fluoro-1,2-dimethoxybenzene (CAS: 398-62-9) typically synthesized?

4-Fluoro-1,2-dimethoxybenzene can be synthesized through a two-step process. In the first step, methylation of o-dichlorobenzene yields 1,2-dimethoxybenzene. In the second step, this intermediate is fluorinated using hydrogen fluoride or triflic anhydride to introduce the fluoro group, yielding the target compound. The synthesis typically involves careful temperature control to achieve high yield and selectivity.

What industries use 4-Fluoro-1,2-dimethoxybenzene (CAS: 398-62-9)?

4-Fluoro-1,2-dimethoxybenzene finds applications in various industries. It is used as an intermediate in the pharmaceutical industry for the synthesis of certain drugs. In the polymer industry, it is utilized in the production of certain types of plastics and resins. Additionally, it has potential uses in the semiconductor industry for specific chemical processes. Its reactivity makes it valuable in analytical chemistry for sensor development.

What precautions should be taken when handling 4-Fluoro-1,2-dimethoxybenzene (CAS: 398-62-9)?

When handling 4-Fluoro-1,2-dimethoxybenzene, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. It should be stored in a well-ventilated area and handled under a fume hood to prevent inhalation. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. In case of contact with skin or eyes, immediately flush with plenty of water and seek medical attention. Safety data sheets (SDS) should be consulted for detailed information on safety and handling procedures.