Compound Q&A

How is 4-Fluoro-1,2-dimethoxybenzene (CAS: 398-62-9) typically synthesized?

Answer

4-Fluoro-1,2-dimethoxybenzene
4-Fluoro-1,2-dimethoxybenzene can be synthesized through a two-step process. In the first step, methylation of o-dichlorobenzene yields 1,2-dimethoxybenzene. In the second step, this intermediate is fluorinated using hydrogen fluoride or triflic anhydride to introduce the fluoro group, yielding the target compound. The synthesis typically involves careful temperature control to achieve high yield and selectivity.

About

CAS No 398-62-9
English Name 4-Fluoro-1,2-dimethoxybenzene
Molecular Formula C8H9FO2
Molecular Weight 156.16 g/mol
SMILES COC1=C(C=C(C=C1)F)OC
InChIKey DAGKHJDZYJFWSO-UHFFFAOYSA-N
Last Updated: 2025-10-19 20:30

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