4-Methoxy-3-(trifluoromethyl)aniline

Basic Information

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CAS Number

393-15-7

Molecular Formula

C8H8F3NO

Molecular Weight

191.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

59-60 ºC

Boiling Point

249.7±40.0 ºC (760 Torr),

Flash Point

104.8±27.3 ºC,

Refractive Index

1.476

SMILES

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COC1=C(C=C(C=C1)N)C(F)(F)F

InChI

InChI=1S/C8H8F3NO/c1-13-7-3-2-5(12)4-6(7)8(9,10)11/h2-4H,12H2,1H3

InChIKey

CQJCPOVTPNWVBW-UHFFFAOYSA-N

LogP

2.2962

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

171

Safety Information

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Hazard Statement

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

MFCD00043460
SCHEMBL130594
AM62326
3-trifluoromethyl-4-methoxyaniline
4-Amino-2-trifluoromethylanisole
AKOS000101573
4-methoxy-3-trifluoromethylphenylamine
EN300-12397
Benzenamine, 4-methoxy-3-(trifluoromethyl)-
4-Methoxy-3-trifluoromethylbenzenamine
4-methoxy-3-trifluoromethyl aniline
393-15-7
[4-methoxy-3-(trifluoromethyl)phenyl]amine hydrochloride
CS-W010728
4-Methoxy-3-trifluoromethyl-phenylamine
BDBM626001
DTXSID60344957
Z119989824
FT-0619982
4-Methoxy-3-trifluoromethyl- phenylamine
3-amino-6-methoxybenzotrifluoride
4-methoxy-3-(trifluoromethyl)aniline
4-methoxy-3-(trifluoromethyl)benzenamine
SY008193
5-Amino-2-methoxybenzotrifluoride, AldrichCPR
2,5-Difluorobenzenesulphonylchloride
4-Methoxy-2-(trifluoromethyl)phenylamine #
AC-10153
AS-39286
3-Trifluoromethyl-p-anisidine
5-Amino-2-methoxybenzotrifluoroide

MDL Number

MFCD00043460

Customs Code

2922299090

FAQ

What are the physical and chemical properties of 4-Methoxy-3-(trifluoromethyl)aniline (CAS: 393-15-7)?

4-Methoxy-3-(trifluoromethyl)aniline has a crystalline form and a molecular weight of approximately 268.08 g/mol. It is slightly soluble in water but more soluble in organic solvents such as ethanol and methanol. Chemically, it is stable under normal conditions but may react with strong reducing agents.

How is 4-Methoxy-3-(trifluoromethyl)aniline (CAS: 393-15-7) typically synthesized?

4-Methoxy-3-(trifluoromethyl)aniline is typically synthesized via the Friedel-Crafts alkylation of aniline with methyl trifluoromethyl ketone in the presence of aluminum chloride. The process yields a pure product with high selectivity and a good yield (up to 80%).

What industries use 4-Methoxy-3-(trifluoromethyl)aniline (CAS: 393-15-7)?

4-Methoxy-3-(trifluoromethyl)aniline is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry for the production of special polymers, and in the sensor industry for the development of chemical sensors. It is also used in semiconductor applications for the fabrication of electronic materials.

What precautions should be taken when handling 4-Methoxy-3-(trifluoromethyl)aniline (CAS: 393-15-7)?

When handling 4-Methoxy-3-(trifluoromethyl)aniline, use proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.