4-Methoxy-3-(trifluoromethyl)aniline(CAS: 393-15-7)

CAS Number
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Basic Information
Molecular Formula
C8H8F3NO
Molecular Weight
191.15 g/mol
Physical Properties
Melting Point
59-60 ºC
Boiling Point
249.7±40.0 ºC (760 Torr),
Flash Point
104.8±27.3 ºC,
Chemical Identifiers
SMILES
COC1=C(C=C(C=C1)N)C(F)(F)F
InChIKey
CQJCPOVTPNWVBW-UHFFFAOYSA-N
Database References
MDL Number
MFCD00043460
Beilstein Registry Number
2723972
FAQ
4-Methoxy-3-(trifluoromethyl)aniline has a crystalline form and a molecular weight of approximately 268.08 g/mol. It is slightly soluble in water but more soluble in organic solvents such as ethanol and methanol. Chemically, it is stable under normal conditions but may react with strong reducing agents.
4-Methoxy-3-(trifluoromethyl)aniline is typically synthesized via the Friedel-Crafts alkylation of aniline with methyl trifluoromethyl ketone in the presence of aluminum chloride. The process yields a pure product with high selectivity and a good yield (up to 80%).
4-Methoxy-3-(trifluoromethyl)aniline is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry for the production of special polymers, and in the sensor industry for the development of chemical sensors. It is also used in semiconductor applications for the fabrication of electronic materials.
What precautions should be taken when handling 4-Methoxy-3-(trifluoromethyl)aniline (CAS: 393-15-7)?
When handling 4-Methoxy-3-(trifluoromethyl)aniline, use proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.
Safety Notice
Please verify product specifications and safety data before use. Contact the supplier for detailed safety information.
Always follow proper handling procedures
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