2-(Chloromethyl)pyrazine

Basic Information

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CAS Number

39204-47-2

Molecular Formula

C5H5ClN2

Molecular Weight

128.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CN=C(C=N1)CCl

InChI

InChI=1S/C5H5ClN2/c6-3-5-4-7-1-2-8-5/h1-2,4H,3H2

InChIKey

GFHPSQFCHUIFTO-UHFFFAOYSA-N

LogP

1.2154

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

67.4

Synonyms & References

English

chloromethylpyrazine
(Chloromethyl)pyrazine
pyrazinylmethyl chloride
2-(Chloromethyl)pyrazine (HCl)
Pyrazine, 2-(chloromethyl)-
AS-33435
EINECS 254-353-2
2-(chloromethyl)pyrazine
AM100758
J-506324
E57G47M2RW
GFHPSQFCHUIFTO-UHFFFAOYSA-N
CS-0053751
AKOS015940574
2-Chloromethyl-pyrazine
NS00030540
FT-0684701
Pyrazine, (chloromethyl)-
PB20483
MFCD10697790
DTXSID4068167
2-(chloromethyl)-pyrazine
2-Chloromethylpyrazine
SCHEMBL246396
F2167-4934
39204-47-2
2-(Chloromethyl)pyrazine
(CHLOROMETHYL)PYRAZINE
3-Butynoicacid,2-[[(1,1-dimethylethoxy)carbonyl]amino]-,methylester(9CI)

MDL Number

MFCD10697790

FAQ

What are the physical and chemical properties of 2-(Chloromethyl)pyrazine (CAS: 39204-47-2)?

2-(Chloromethyl)pyrazine is a crystalline solid with a molecular weight of approximately 131.54 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. It is stable under normal storage conditions but should be protected from moisture and strong oxidizing agents.

How is 2-(Chloromethyl)pyrazine (CAS: 39204-47-2) typically synthesized?

2-(Chloromethyl)pyrazine is typically synthesized by the reaction of chloromethyl ketone with pyrazine in the presence of a base such as potassium hydroxide. The yield is around 85%, and the reaction is conducted in an inert atmosphere to prevent oxidation. This method allows for the production of the compound with good selectivity and purity.

What industries use 2-(Chloromethyl)pyrazine (CAS: 39204-47-2)?

2-(Chloromethyl)pyrazine finds applications in the pharmaceutical industry for the synthesis of certain drug molecules. It is also used in the sensor industry for developing gas sensors and in the semiconductor industry for the production of certain compounds used in manufacturing processes. Additionally, it has potential uses in polymer chemistry for the modification of polymers.

What precautions should be taken when handling 2-(Chloromethyl)pyrazine (CAS: 39204-47-2)?

When handling 2-(Chloromethyl)pyrazine, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or in a fume hood to avoid inhalation or skin contact. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.