Compound Q&A

How is 2-(Chloromethyl)pyrazine (CAS: 39204-47-2) typically synthesized?

Answer

2-(Chloromethyl)pyrazine
2-(Chloromethyl)pyrazine is typically synthesized by the reaction of chloromethyl ketone with pyrazine in the presence of a base such as potassium hydroxide. The yield is around 85%, and the reaction is conducted in an inert atmosphere to prevent oxidation. This method allows for the production of the compound with good selectivity and purity.

About

CAS No 39204-47-2
English Name 2-(Chloromethyl)pyrazine
Molecular Formula C5H5ClN2
Molecular Weight 128.56 g/mol
SMILES C1=CN=C(C=N1)CCl
InChIKey GFHPSQFCHUIFTO-UHFFFAOYSA-N
Last Updated: 2025-11-07 19:01

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