Lapatinib Ditosylate

Basic Information

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CAS Number

388082-77-7

Molecular Formula

C43H42ClFN4O10S3

Molecular Weight

925.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

240-242°C

Boiling Point

750.7°C at 760 mmHg

SMILES

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CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

InChI

InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)

InChIKey

UWYXLGUQQFPJRI-UHFFFAOYSA-N

LogP

8.622540000000003

Topological Polar Surface Area

215.08999999999997 Å²

Hydrogen Bond Donor/Acceptor

4 / 14

Complexity

1100

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SR-05000001472-5
HMS3265J13
4-Methylbenzene-1-sulfonic acid--N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine (2/1)
HMS3265I13
Lapatinib ditosylate anhydrous
4-QUINAZOLINAMINE, N-(3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)-6-(5-(((2-(METHYLSULFONYL)ETHYL)AMINO)METHYL)-2-FURANYL)-, 4-METHYLBENZENESULFONATE (1:2)
388082-77-7 (ditosylate)
388082-77-7
N-(3-CHLORO-4-((3-FLUOROBENZYL)OXY)PHENYL)-6-(5-(((2-(METHYLSULFONYL)ETHYL)AMINO)METHYL)FURAN-2-YL)QUINAZOLIN-4-AMINE BIS(4-METHYLBENZENESULFONATE)
HY-50898A
Z1692482592
S1028
Lapatinib (GW-572016) Ditosylate
SR-05000001472
FT-0670728
Tykerb Ditosylate
DTXSID60959606
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl) ethylamino)methyl)furan-2-yl)quinazolin-4-amine ditosylate
HMS3265I14
bis(4-methylbenzene-1-sulfonic acid); N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine bis(4-methylbenzenesulfona
SW199101-4
N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine ditosylate
SCHEMBL93590
LAPATINIB DITOLUENESULFONATE ANHYDROUS [MI]
Lapatinib Ditosylate
AC-5247
HMS3654E07
GW-572016 ditosylate
GS-3661
Lapatinib Ditosylate (GW-572016)

MDL Number

MFCD09264195

Customs Code

29420000

FAQ

What is Lapatinib Ditosylate (CAS: 388082-77-7)?

Lapatinib Ditosylate (CAS: 388082-77-7) is a pharmaceutical compound used as a tyrosine kinase inhibitor. Its chemical formula is C21H26N2O11S2, and it is a white, crystalline powder with high water solubility. It is commonly used in drug formulations for cancer treatment, particularly targeting HER2-positive breast cancer. The tosylate salt form enhances its stability and bioavailability in medicinal applications.

What are the main uses of Lapatinib Ditosylate (CAS: 388082-77-7)?

Lapatinib Ditosylate (CAS: 388082-77-7) is primarily used in pharmaceuticals as a targeted therapy for HER2-positive breast cancer. It inhibits the growth of cancer cells by blocking specific protein receptors. Additionally, it is employed in research for studying kinase pathways and in drug development for creating cancer treatment options. Its applications are limited to medicinal and scientific fields due to its specialized chemical properties.

Is Lapatinib Ditosylate (CAS: 388082-77-7) safe?

Lapatinib Ditosylate (CAS: 388082-77-7) is generally safe when used as directed in medical settings. However, it may cause side effects such as diarrhea, nausea, and fatigue. Handling precautions include wearing gloves and eye protection to avoid skin contact or inhalation. Safety standards require proper storage and administration by trained professionals to ensure efficacy and minimize risks.

How should Lapatinib Ditosylate (CAS: 388082-77-7) be stored?

Lapatinib Ditosylate (CAS: 388082-77-7) should be stored in a cool, dry place at 2-8°C, protected from light. Keep it in a sealed, airtight container made of glass or plastic to prevent moisture absorption. Avoid exposure to high humidity or extreme temperatures to maintain chemical stability. Storage conditions should comply with pharmaceutical guidelines to preserve potency and safety.