6-(Trifluoromethyl)nicotinaldehyde

Basic Information

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CAS Number

386704-12-7

Molecular Formula

C7H4F3NO

Molecular Weight

175.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

No data available

Melting Point

56.0 to 60.0 deg-C

Boiling Point

205.3°C at 760 mmHg

Density

1.369

Refractive Index

1.476

SMILES

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C1=CC(=NC=C1C=O)C(F)(F)F

InChI

InChI=1S/C7H4F3NO/c8-7(9,10)6-2-1-5(4-12)3-11-6/h1-4H

InChIKey

MRPAGRCGPAXOGS-UHFFFAOYSA-N

LogP

1.9128999999999998

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

169

Safety Information

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GHS Hazard Pictograms

H301

H315

H317

H319

H335

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Sensitiveness

Air Sensitive

Synonyms & References

English

6-Trifluoromethyl-pyridine-3-carbaldehyde
6-(trifluoro-methyl)nicotinaldehyde
MFCD01862647
J-518130
AKOS005063357
Z1160902361
5-formyl-2-(trifluoromethyl)pyridine
6-(trifluoromethyl)-3-pyridinecarbaldehyde
6-(Trifluoromethyl)pyridine-3-carboxaldehyde
FT-0649575
6-(Trifluoromethyl)-3-pyridinecarboxaldehyde
SY002806
6-(Trifluoromethyl)nicotinaldehyde
6-(trifluoromethyl)pyridine-3-carbaldehyde
AM20051134
6-(Trifluoromethyl)pyridine-3-carboxaldehyde, 95%
LB-0717
CS-W008718
3-pyridinecarboxaldehyde, 6-(trifluoromethyl)-
6-(trifluoromethyl) nicotinaldehyde
2-(trifluoromethyl)pyridine-5-carboxaldehyde
6-trifluoromethyl-pyridine-3-carboxaldehyde
EN300-1440255
BCP26794
SCHEMBL336320
DTXSID90380641
T2838
6-trifluoromethyl-3-pyridinecarboxaldehyde
A6531
6-Trifluoromethylpyridine-3-carbaldehyde
BP-13321

MDL Number

MFCD01862647

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-(Trifluoromethyl)nicotinaldehyde (CAS: 386704-12-7)?

6-(Trifluoromethyl)nicotinaldehyde is a white or off-white crystalline solid with a molecular weight of approximately 232.1 g/mol. It has a solubility of 4.9 g/L in water at 25°C. Chemically, it is highly reactive, especially towards nucleophiles and reducing agents.

How is 6-(Trifluoromethyl)nicotinaldehyde (CAS: 386704-12-7) typically synthesized?

6-(Trifluoromethyl)nicotinaldehyde is typically synthesized via a condensation reaction between 6-(trifluoromethyl)nicotinic acid and appropriate aldehydes, catalyzed by a suitable reagent like phosphorous oxychloride. The process yields a high-quality product with good selectivity and high yield.

What industries use 6-(Trifluoromethyl)nicotinaldehyde (CAS: 386704-12-7)?

6-(Trifluoromethyl)nicotinaldehyde finds applications in the pharmaceutical industry for the synthesis of various drug molecules, as well as in the polymer industry for the production of high-performance polymers. It is also used in the manufacturing of sensors and as a precursor in semiconductor processing.

What precautions should be taken when handling 6-(Trifluoromethyl)nicotinaldehyde (CAS: 386704-12-7)?

When handling 6-(Trifluoromethyl)nicotinaldehyde, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or under a fume hood. Spills should be immediately cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling instructions.