6-(Trifluoromethyl)nicotinaldehyde(CAS: 386704-12-7)

6-(Trifluoromethyl)nicotinaldehyde is a white or off-white crystalline solid with a molecular weight of approximately 232.1 g/mol. It has a solubility of 4.9 g/L in water at 25°C. Chemically, it is highly reactive, especially towards nucleophiles and reducing agents.

6-(Trifluoromethyl)nicotinaldehyde is typically synthesized via a condensation reaction between 6-(trifluoromethyl)nicotinic acid and appropriate aldehydes, catalyzed by a suitable reagent like phosphorous oxychloride. The process yields a high-quality product with good selectivity and high yield.

6-(Trifluoromethyl)nicotinaldehyde finds applications in the pharmaceutical industry for the synthesis of various drug molecules, as well as in the polymer industry for the production of high-performance polymers. It is also used in the manufacturing of sensors and as a precursor in semiconductor processing.

When handling 6-(Trifluoromethyl)nicotinaldehyde, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or under a fume hood. Spills should be immediately cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling instructions.