2-Chloro-1,3-difluorobenzene

Basic Information

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CAS Number

38361-37-4

Molecular Formula

C6H3ClF2

Molecular Weight

148.54 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

131°C

Refractive Index

1.4780-1.4820

SMILES

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C1=CC(=C(C(=C1)F)Cl)F

InChI

InChI=1S/C6H3ClF2/c7-6-4(8)2-1-3-5(6)9/h1-3H

InChIKey

OTZQYBFTOANOJO-UHFFFAOYSA-N

LogP

2.6182000000000007

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

87.1

Safety Information

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GHS Hazard Pictograms

H226

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

Hazard Class

Class 3 Class 3

Synonyms & References

English

AM20040337
2-Chloro-1,3-difluoro-benzene
SY040901
FT-0639461
2-Chloro-1,3-difluorobenzene
MFCD00142604
m-difluorochlorobenzene
A6505
CS-W018183
2,6-difluorochlorobenzene
chloro-2,6-difluorobenzene
AKOS006228199
2,6-Diflurochlorobenzene
EN300-123125
SCHEMBL1042133
38361-37-4
OTZQYBFTOANOJO-UHFFFAOYSA-N
Benzene, 2-chloro-1,3-difluoro-
C2211
AS-30439
1-Chloro-2,6-difluorobenzene
DTXSID90191719
Benzene,2-chloro-1,3-difluoro-
2,6-Difluorochlorobenzene
PubChem3416
KSC493C7B
1-Chloro-2,6 Difluorobenzene
WT1555
SBB086607
LF10634
AS02693

MDL Number

MFCD00142604

Customs Code

2903999090

FAQ

What are the physical and chemical properties of 2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4)?

2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4) is a crystalline solid with a molecular weight of approximately 170.58 g/mol. It has a low solubility in water but is soluble in organic solvents like benzene, chloroform, and ethanol. This compound is relatively stable but can react with strong bases and reducing agents. It is used in the synthesis of pharmaceuticals and polymers due to its reactivity and chemical versatility.

How is 2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4) typically synthesized?

2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4) can be synthesized via the Friedel-Crafts alkylation of 1,3-difluorobenzene with chlorine. The reaction is typically carried out in the presence of a Lewis acid such as aluminum chloride to facilitate the electrophilic aromatic substitution. High yield and selectivity can be achieved under controlled conditions, ensuring the formation of the desired product.

What industries use 2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4)?

2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4) is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various pharmaceutical compounds and also finds applications in the production of polymers and organic semiconductors. Additionally, it can be used in the development of sensors and other advanced materials.

What precautions should be taken when handling 2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4)?

When handling 2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a laboratory coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be immediately cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.