Compound Q&A

How is 2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4) typically synthesized?

Answer

2-Chloro-1,3-difluorobenzene
2-Chloro-1,3-difluorobenzene (CAS: 38361-37-4) can be synthesized via the Friedel-Crafts alkylation of 1,3-difluorobenzene with chlorine. The reaction is typically carried out in the presence of a Lewis acid such as aluminum chloride to facilitate the electrophilic aromatic substitution. High yield and selectivity can be achieved under controlled conditions, ensuring the formation of the desired product.

About

CAS No 38361-37-4
English Name 2-Chloro-1,3-difluorobenzene
Molecular Formula C6H3ClF2
Molecular Weight 148.54 g/mol
SMILES C1=CC(=C(C(=C1)F)Cl)F
InChIKey OTZQYBFTOANOJO-UHFFFAOYSA-N
Last Updated: 2025-10-10 13:51

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