(2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol

Basic Information

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CAS Number

38304-91-5

Molecular Formula

C9H15N5O

Molecular Weight

209.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

272-274 °C (dec.)

Boiling Point

351.7°C at 760 mmHg

Water Solubility

Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.

Refractive Index

1.7610 (estimate)

SMILES

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Nc1cc(nc(N)[n+]1[O-])N2CCCCC2

InChI

InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2/b11-9+

InChIKey

ZIMGGGWCDYVHOY-PKNBQFBNSA-N

LogP

0.91830

pKa

4.61(at 25℃)

Complexity

329

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Toxicity

LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra)

Synonyms & References

English

loniten
2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE 3-OXIDE
6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE 3-OXIDE
6-(1-PIPERIDINYL)PYRIMIDINE-2,4-DIAMINE 3-OXIDE
MONOXIDIL
regain
rogaine
U-10858
2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
2,4-diamino-6-piperidinilpirimidina-3-ossido
2,4-diamino-6-piperidino-pyrimidin3-oxide
2,4-diamino-6-piperidinopyrimidine3-n-oxide
4-pyrimidinediamine,6-(1-piperidinyl)-3-oxide
6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
6-piperidino-2,4-diaminopyrimidine3-oxide
alopexil
alostil
lonolox
minossidile
Minoxidil
3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
U10858
2,4-diamino-6-piperidino-pyrimidine-3-oxide
2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide
2,6-Diamino-4-piperidinopyrimidine 1-Oxide
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide (6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-dia
Minoximen
Regaine
Theroxidil
Tricoxidil

MDL Number

MFCD00072128

FAQ

What is (2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5)?

(2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5) is a pyrimidine derivative with a piperidine ring. Its molecular formula is C9H15N5O, featuring amino, imino, and hydroxyl functional groups. The compound exhibits polarity due to hydroxyl groups and is typically used in pharmaceutical research. It is a key intermediate in drug synthesis, known for its structural versatility in medicinal chemistry applications.

What are the main uses of (2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5)?

(2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5) is primarily used in pharmaceutical research for developing antiviral and antibiotic drugs. Its structure allows modification into various bioactive molecules. It also serves as an industrial chemical in synthetic pathways and is studied in research for its potential in targeting specific enzymes or receptors. Applications span drug discovery, chemical synthesis, and medicinal research.

Is (2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5) safe?

Safety data for (2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5) is limited, but general handling precautions apply. It may cause skin or eye irritation, so use gloves, goggles, and ventilation. Avoid ingestion or inhalation. Safety standards recommend following OSHA guidelines for chemical exposure. Proper disposal is essential to prevent environmental contamination.

How should (2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5) be stored?

(2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol (CAS: 38304-91-5) should be stored in a cool, dry place (≤25°C) away from light. Keep in a sealed, airtight container to prevent moisture absorption. Avoid exposure to strong oxidizing agents. Stability is maintained under standard conditions, but long-term storage requires controlled humidity and temperature to preserve chemical integrity.